TY - JOUR
T1 - NOrmalized MAgnetization Ratio (NOMAR) filtering for creation of tissue selective contrast maps
AU - Liu, Guanshu
AU - Chan, Kannie W. Y.
AU - Song, Xiaolei
AU - Zhang, Jiangyang
AU - Gilad, Assaf A.
AU - Bulte, Jeff W. M.
AU - Van Zijl, Peter C. M.
AU - McMahon, Michael T.
PY - 2013/2
Y1 - 2013/2
N2 - An MRI segmentation technique based on collecting two additional saturation transfer images is proposed as an aid for improved detection of chemical exchange saturation transfer agents. In this approach, the additional images are acquired at saturation frequencies of -12.5 and -50 ppm. Use of the ratio of these images allows differentiation of voxels with low magnetization transfer contrast (such as fat, cerebrospinal fluid, edema, or blood) from target tissue voxels using a global threshold determined by histogram analysis. We demonstrate that this technique can reduce artifacts, in vitro, in a phantom containing tubes with chemical exchange saturation transfer contrast agent embedded in either crosslinked bovine serum albumin or buffer, and in vivo for detecting diamagnetic CEST (DIACEST) liposomes injected into mice. Magn Reson Med, 2013. © 2012 Wiley Periodicals, Inc. Copyright © 2012 Wiley Periodicals, Inc.
AB - An MRI segmentation technique based on collecting two additional saturation transfer images is proposed as an aid for improved detection of chemical exchange saturation transfer agents. In this approach, the additional images are acquired at saturation frequencies of -12.5 and -50 ppm. Use of the ratio of these images allows differentiation of voxels with low magnetization transfer contrast (such as fat, cerebrospinal fluid, edema, or blood) from target tissue voxels using a global threshold determined by histogram analysis. We demonstrate that this technique can reduce artifacts, in vitro, in a phantom containing tubes with chemical exchange saturation transfer contrast agent embedded in either crosslinked bovine serum albumin or buffer, and in vivo for detecting diamagnetic CEST (DIACEST) liposomes injected into mice. Magn Reson Med, 2013. © 2012 Wiley Periodicals, Inc. Copyright © 2012 Wiley Periodicals, Inc.
KW - chemical exchange saturation transfer (CEST)
KW - magnetization transfer (MT)
KW - MRI segmentation
UR - http://www.scopus.com/inward/record.url?scp=84872899963&partnerID=8YFLogxK
UR - https://www.scopus.com/record/pubmetrics.uri?eid=2-s2.0-84872899963&origin=recordpage
U2 - 10.1002/mrm.24271
DO - 10.1002/mrm.24271
M3 - RGC 21 - Publication in refereed journal
C2 - 22499503
SN - 0740-3194
VL - 69
SP - 516
EP - 523
JO - Magnetic Resonance in Medicine
JF - Magnetic Resonance in Medicine
IS - 2
ER -