Nonleaching Antibacterial Concept Demonstrated by In Situ Construction of 2D Nanoflakes on Magnesium
Research output: Journal Publications and Reviews › RGC 21 - Publication in refereed journal › peer-review
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Detail(s)
Original language | English |
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Article number | 1902089 |
Journal / Publication | Advanced Science |
Volume | 7 |
Issue number | 1 |
Online published | 30 Sept 2019 |
Publication status | Published - 8 Jan 2020 |
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DOI | DOI |
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Attachment(s) | Documents
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Link to Scopus | https://www.scopus.com/record/display.uri?eid=2-s2.0-85073964887&origin=recordpage |
Permanent Link | https://scholars.cityu.edu.hk/en/publications/publication(ebfd2b4f-0007-4ef0-a232-beff431314f3).html |
Abstract
In bone implants, antibacterial biomaterials with nonleaching surfaces are superior to ones based on abrupt release because systemic side effects arising from the latter can be avoided. In this work, a nonleaching antibacterial concept is demonstrated by fabricating 2D nanoflakes in situ on magnesium (Mg). Different from the conventional antibacterial mechanisms that depend on Mg2+ release and pH increase, the nanoflakes exert mechanical tension onto the bacteria membranes to destroy microorganisms on contact and produce intracellular stress via physical interactions, which is also revealed by computational simulations. Moreover, the nanoflake layer decelerates the corrosion process resulting in mitigated Mg2+ release, weaker alkalinity in the vicinity, and less hydrogen evolution, in turn inducing less inflammatory reactions and ensuring the biocompatibility as confirmed by the in vivo study. In this way, bacteria are killed by a mechanical process causing very little side effects. This work provides information and insights pertaining to the design of multifunctional biomaterials. © 2019 The Authors. Published by WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.
Research Area(s)
- antibacterial, magnesium, nanoflake, nonleaching
Citation Format(s)
Nonleaching Antibacterial Concept Demonstrated by In Situ Construction of 2D Nanoflakes on Magnesium. / Wang, Guomin; Jiang, Wenjuan; Mo, Shi et al.
In: Advanced Science, Vol. 7, No. 1, 1902089, 08.01.2020.
In: Advanced Science, Vol. 7, No. 1, 1902089, 08.01.2020.
Research output: Journal Publications and Reviews › RGC 21 - Publication in refereed journal › peer-review
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