Non-invasive controlled release from gold nanoparticle integrated photo-responsive liposomes through pulse laser induced microbubble cavitation

Research output: Journal Publications and Reviews (RGC: 21, 22, 62)21_Publication in refereed journalpeer-review

21 Scopus Citations
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Author(s)

  • Malathi Mathiyazhakan
  • Yuanxiang Yang
  • Yibo Liu
  • Caigang Zhu
  • Quan Liu
  • Claus-Dieter Ohl
  • Kam Chiu Tam
  • Yu Gao

Detail(s)

Original languageEnglish
Pages (from-to)569-574
Journal / PublicationColloids and Surfaces B: Biointerfaces
Volume126
Online published22 Nov 2014
Publication statusPublished - 1 Feb 2015
Externally publishedYes

Abstract

Drug-carriers, capable of releasing the drug at the target sites upon external stimuli, are attractive for theranostic applications. In recent years, photo-responsive nanoparticles (NPs) have received considerable attention because of their potentials in providing spatial, temporal, and dosage control over the drug release. However, most of the relevant technologies are still in the process of development and are unprocurable by the clinics. Here, we demonstrated facile fabrication of these photo-responsive NPs by loading hydrophilic gold NPs within thermo-responsive liposomes. Calcein was used as a model drug to evaluate the encapsulation efficiency and the release kinetic profile upon heat/light stimulation. Furthermore, we characterized their size, morphology, phase transition temperature and stability. Finally, we demonstrated that this photo-triggered release might be due to the membrane disruption caused by microbubble cavitation.

Research Area(s)

  • Controlled release, Drug delivery, Exogenous stimuli-responsive nanoparticles, Gold nanoparticles, Microbubble cavitation, Thermal-responsive liposome

Citation Format(s)

Non-invasive controlled release from gold nanoparticle integrated photo-responsive liposomes through pulse laser induced microbubble cavitation. / Mathiyazhakan, Malathi; Yang, Yuanxiang; Liu, Yibo; Zhu, Caigang; Liu, Quan; Ohl, Claus-Dieter; Tam, Kam Chiu; Gao, Yu; Xu, Chenjie.

In: Colloids and Surfaces B: Biointerfaces, Vol. 126, 01.02.2015, p. 569-574.

Research output: Journal Publications and Reviews (RGC: 21, 22, 62)21_Publication in refereed journalpeer-review