Non B Cell-Derived Immunoglobulin, A Brighter Horizon for the Future

Ming Chu; Ning Fu; Liang Zhang; Meng Yu; Youhui Zhang; Xiaoyan Qiu

doi:10.1007/978-981-97-0511-5_1

Non B Cell-Derived Immunoglobulin, A Brighter Horizon for the Future

Ming Chu
, Ning Fu
, Liang Zhang
, Meng Yu
, Youhui Zhang
, Xiaoyan Qiu

Department of Biomedical Sciences

Research output: Chapters, Conference Papers, Creative and Literary Works › RGC 12 - Chapter in an edited book (Author) › peer-review

1 Citation (Scopus)

Abstract

The canonical theory of immunology stating that "Immunoglobulin (Ig) is produced by B lymphocytes and exerts antibody activity" has been established since the 1970s. However, the discovery of non B cell-derived Igs (non B-Igs), which can exert multiple biological activities in addition to their antibody activities, necessitates a reevaluation of the classic concept of Ig. This has been documented with a number of characteristics related to their structure, modification, genetic regulation as well as the functions associated with clinical conditions, particularly multiple cancers. The discovery of non B-Ig provides us with a new perspective to better understand not only basic immunology, but also various Ig-related clinical manifestations including autoimmune diseases, chronic inflammation, and anaphylaxis. Notably, non B-Ig can directly promote the occurrence of malignant tumours. © 2024. Springer Nature Singapore Pte Ltd.

Original language	English
Title of host publication	Non B cell-Derived Immunoglobulins
Subtitle of host publication	The Structure, Characteristics and the Implication on Clinical Medicine
Editors	Xiaoyan Qiu, Jing Huang, Xiaojun Xu
Publisher	Springer
Pages	3-10
Edition	1
ISBN (Electronic)	978-981-97-0511-5, 978-981-97-0513-9
ISBN (Print)	978-981-97-0510-8
DOIs	https://doi.org/10.1007/978-981-97-0511-5_1
Publication status	Published - Jul 2024

Publication series

Name	Advances in experimental medicine and biology
Volume	1445
ISSN (Print)	0065-2598

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being

Research Keywords

Non B cell-derived immunoglobulins (non B-Igs)

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10.1007/978-981-97-0511-5_1

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Chu, M., Fu, N., Zhang, L., Yu, M., Zhang, Y., & Qiu, X. (2024). Non B Cell-Derived Immunoglobulin, A Brighter Horizon for the Future. In X. Qiu, J. Huang, & X. Xu (Eds.), Non B cell-Derived Immunoglobulins: The Structure, Characteristics and the Implication on Clinical Medicine (1 ed., pp. 3-10). (Advances in experimental medicine and biology; Vol. 1445). Springer . https://doi.org/10.1007/978-981-97-0511-5_1

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Chu, M, Fu, N, Zhang, L, Yu, M, Zhang, Y & Qiu, X 2024, Non B Cell-Derived Immunoglobulin, A Brighter Horizon for the Future. in X Qiu, J Huang & X Xu (eds), Non B cell-Derived Immunoglobulins: The Structure, Characteristics and the Implication on Clinical Medicine. 1 edn, Advances in experimental medicine and biology, vol. 1445, Springer , pp. 3-10. https://doi.org/10.1007/978-981-97-0511-5_1

Non B Cell-Derived Immunoglobulin, A Brighter Horizon for the Future. / Chu, Ming; Fu, Ning; Zhang, Liang et al.
Non B cell-Derived Immunoglobulins: The Structure, Characteristics and the Implication on Clinical Medicine. ed. / Xiaoyan Qiu; Jing Huang; Xiaojun Xu . 1. ed. Springer , 2024. p. 3-10 (Advances in experimental medicine and biology; Vol. 1445).

Research output: Chapters, Conference Papers, Creative and Literary Works › RGC 12 - Chapter in an edited book (Author) › peer-review

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AU - Qiu, Xiaoyan

PY - 2024/7

Y1 - 2024/7

N2 - The canonical theory of immunology stating that "Immunoglobulin (Ig) is produced by B lymphocytes and exerts antibody activity" has been established since the 1970s. However, the discovery of non B cell-derived Igs (non B-Igs), which can exert multiple biological activities in addition to their antibody activities, necessitates a reevaluation of the classic concept of Ig. This has been documented with a number of characteristics related to their structure, modification, genetic regulation as well as the functions associated with clinical conditions, particularly multiple cancers. The discovery of non B-Ig provides us with a new perspective to better understand not only basic immunology, but also various Ig-related clinical manifestations including autoimmune diseases, chronic inflammation, and anaphylaxis. Notably, non B-Ig can directly promote the occurrence of malignant tumours. © 2024. Springer Nature Singapore Pte Ltd.

AB - The canonical theory of immunology stating that "Immunoglobulin (Ig) is produced by B lymphocytes and exerts antibody activity" has been established since the 1970s. However, the discovery of non B cell-derived Igs (non B-Igs), which can exert multiple biological activities in addition to their antibody activities, necessitates a reevaluation of the classic concept of Ig. This has been documented with a number of characteristics related to their structure, modification, genetic regulation as well as the functions associated with clinical conditions, particularly multiple cancers. The discovery of non B-Ig provides us with a new perspective to better understand not only basic immunology, but also various Ig-related clinical manifestations including autoimmune diseases, chronic inflammation, and anaphylaxis. Notably, non B-Ig can directly promote the occurrence of malignant tumours. © 2024. Springer Nature Singapore Pte Ltd.

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Chu M, Fu N, Zhang L, Yu M, Zhang Y, Qiu X. Non B Cell-Derived Immunoglobulin, A Brighter Horizon for the Future. In Qiu X, Huang J, Xu X, editors, Non B cell-Derived Immunoglobulins: The Structure, Characteristics and the Implication on Clinical Medicine. 1 ed. Springer . 2024. p. 3-10. (Advances in experimental medicine and biology). Epub 2024 Jul 6. doi: 10.1007/978-981-97-0511-5_1

Non B Cell-Derived Immunoglobulin, A Brighter Horizon for the Future

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