Nitric Oxide Nanosensors for Predicting the Development of Osteoarthritis in Rat Model

Research output: Journal Publications and Reviews (RGC: 21, 22, 62)21_Publication in refereed journalpeer-review

29 Scopus Citations
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Author(s)

  • Pan Jin
  • Christian Wiraja
  • Jinmin Zhao
  • Jinlu Zhang
  • Li Zheng

Detail(s)

Original languageEnglish
Pages (from-to)25128-25137
Journal / PublicationACS Applied Materials and Interfaces
Volume9
Issue number30
Online published10 Jul 2017
Publication statusPublished - 2 Aug 2017
Externally publishedYes

Abstract

Osteoarthritis (OA) is a chronic arthritic disease that causes the overproduction of inflammatory factors such as nitric oxide (NO). This study develops a NO nanosensor to predict the OA development. The nanosensor is synthesized by encapsulating the NO sensing molecules (i.e., 4-amino-5-methylamino-2′,7′-difluorofluorescein Diaminofluorescein-FM (DAF-FM)) within the biodegradable poly(lactic-co-glycolic acid) nanoparticles. In vitro, the nanosensor allows the monitoring of the NO release in interleukin-1β-stimulated chondrocytes and the alleviated effect of NG-monomethyl-L-arginine (a NO inhibitor) and andrographolide (an anti-inflammatory agent). In the rat OA model, it permits the quantification of NO level in joint fluid. The proposed NO nanosensor may facilitate a noninvasive and real-time evaluation of the OA development.

Research Area(s)

  • DAF-FM, nanosensor, nitric oxide sensing, osteoarthritis, PLGA

Citation Format(s)

Nitric Oxide Nanosensors for Predicting the Development of Osteoarthritis in Rat Model. / Jin, Pan; Wiraja, Christian; Zhao, Jinmin; Zhang, Jinlu; Zheng, Li; Xu, Chenjie.

In: ACS Applied Materials and Interfaces, Vol. 9, No. 30, 02.08.2017, p. 25128-25137.

Research output: Journal Publications and Reviews (RGC: 21, 22, 62)21_Publication in refereed journalpeer-review