NIR-II Absorbing Semiconducting Polymer-Triggered Gene-Directed Enzyme Prodrug Therapy for Cancer Treatment

Research output: Journal Publications and Reviews (RGC: 21, 22, 62)21_Publication in refereed journalpeer-review

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Author(s)

  • Xun Zhang
  • Yanqing Yang
  • Tianyi Kang
  • Jun Wang
  • Guang Yang
  • Yuming Yang
  • Xiangwei Lin
  • Kai Li
  • Jie Liu
  • Jen-Shyang Ni

Detail(s)

Original languageEnglish
Article number2100501
Journal / PublicationSmall
Publication statusOnline published - 25 Apr 2021

Abstract

Exploration of facile strategies for precise regulation of target gene expression remains highly challenging in the development of gene therapies. Especially, a stimuli-responsive nanocarrier integrated with ability of noninvasive remote control for treating wide types of cancers is rarely developed. Herein, a NIR-II absorbing semiconducting polymer (PBDTQ) is employed to remotely activate the heat-inducible heat-shock protein 70 (HSP70) promoter under laser irradiation, further realizing regulation of gene-directed enzyme prodrug therapy (GDEPT) for cancer treatment in mild hyperthermia. In this multifunctional nanocomposite, the PBDTQ and double suicide gene plasmid (pSG) based on HSP70 promoter are incorporated into a lipid complex. Upon NIR-II laser excitation, the mild photothermal effect (≈43 °C) generated from PBDTQ can cause the release of pSG and activation of HSP70 promoter, and then upregulate suicide gene expression triggered by the HSP70 promoter which can further convert the nontoxic prodrug into its cytotoxic metabolites. Therefore, this work demonstrates a universal NIR-II laser-triggered GDEPT using semiconducting polymers as the photothermal generator for cancer treatment with minimized collateral damage and nontargeted side effects.

Research Area(s)

  • gene therapy, mild hyperthermia, NIR-II absorption, photothermal therapy, semiconducting polymer

Citation Format(s)

NIR-II Absorbing Semiconducting Polymer-Triggered Gene-Directed Enzyme Prodrug Therapy for Cancer Treatment. / Zhang, Xun; Yang, Yanqing; Kang, Tianyi; Wang, Jun; Yang, Guang; Yang, Yuming; Lin, Xiangwei; Wang, Lidai; Li, Kai; Liu, Jie; Ni, Jen-Shyang.

In: Small, 25.04.2021.

Research output: Journal Publications and Reviews (RGC: 21, 22, 62)21_Publication in refereed journalpeer-review