Nickel-Catalyzed Enantioselective Reductive Amination of Ketones with Both Arylamines and Benzhydrazide
Research output: Journal Publications and Reviews (RGC: 21, 22, 62) › 21_Publication in refereed journal › peer-review
Author(s)
Detail(s)
| Original language | English |
|---|---|
| Pages (from-to) | 12083-12087 |
| Journal / Publication | Angewandte Chemie - International Edition |
| Volume | 55 |
| Issue number | 39 |
| Online published | 30 Aug 2016 |
| Publication status | Published - 19 Sep 2016 |
| Externally published | Yes |
Link(s)
Abstract
An asymmetric reductive amination of ketones using both arylamines and benzhydrazide in the presence of nickel catalysts was developed. A one-pot synthesis of tetrahydroquinoxalines was also developed starting directly from α-ketoaldehydes and 1,2-diaminobenzene. Formic acid was used as a safe and economic surrogate for high-pressure hydrogen gas. Strongly σ-donating bis(alkylphosphine)s are crucial ancillary ligands for both stereoselective hydride insertion and decarboxylation of the formate.
Research Area(s)
- chiral alkylamines, nickel, reductive amination, synthetic methods, transfer hydrogenation
Citation Format(s)
Nickel-Catalyzed Enantioselective Reductive Amination of Ketones with Both Arylamines and Benzhydrazide. / Yang, Peng; Lim, Li Hui; Chuanprasit, Pratanphorn et al.
In: Angewandte Chemie - International Edition, Vol. 55, No. 39, 19.09.2016, p. 12083-12087.Research output: Journal Publications and Reviews (RGC: 21, 22, 62) › 21_Publication in refereed journal › peer-review
