New Water-Soluble Copper(II) Complexes with Morpholine-Thiosemicarbazone Hybrids : Insights into the Anticancer and Antibacterial Mode of Action

Research output: Journal Publications and Reviews (RGC: 21, 22, 62)21_Publication in refereed journalpeer-review

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Author(s)

  • Kateryna Ohui
  • Eleonora Afanasenko
  • Felix Bacher
  • Rachel Lim Xue Ting
  • Ayesha Zafar
  • Núria Blanco-Cabra
  • Eduard Torrents
  • Orsolya Dömötör
  • Nóra V. May
  • Denisa Darvasiova
  • Éva A. Enyedy
  • Ana Popović-Bijelić
  • Jóhannes Reynisson
  • Peter Rapta
  • Giorgia Pastorin
  • Vladimir B. Arion

Detail(s)

Original languageEnglish
Pages (from-to)512-530
Journal / PublicationJournal of Medicinal Chemistry
Volume62
Issue number2
Online published3 Dec 2018
Publication statusPublished - 24 Jan 2019
Externally publishedYes

Abstract

Six morpholine-(iso)thiosemicarbazone hybrids HL1 -HL6 and their Cu(II) complexes with good-to-moderate solubility and stability in water were synthesized and characterized. Cu(II) complexes [Cu(L 1-6 )Cl] (1-6) formed weak dimeric associates in the solid state, which did not remain intact in solution as evidenced by ESI-MS. The lead proligands and Cu(II) complexes displayed higher antiproliferative activity in cancer cells than triapine. In addition, complexes 2-5 were found to specifically inhibit the growth of Gram-positive bacteria Staphylococcus aureus with MIC50 values at 2-5 μg/mL. Insights into the processes controlling intracellular accumulation and mechanism of action were investigated for 2 and 5, including the role of ribonucleotide reductase (RNR) inhibition, endoplasmic reticulum stress induction, and regulation of other cancer signaling pathways. Their ability to moderately inhibit R2 RNR protein in the presence of dithiothreitol is likely related to Fe chelating properties of the proligands liberated upon reduction.

Citation Format(s)

New Water-Soluble Copper(II) Complexes with Morpholine-Thiosemicarbazone Hybrids : Insights into the Anticancer and Antibacterial Mode of Action. / Ohui, Kateryna; Afanasenko, Eleonora; Bacher, Felix et al.

In: Journal of Medicinal Chemistry, Vol. 62, No. 2, 24.01.2019, p. 512-530.

Research output: Journal Publications and Reviews (RGC: 21, 22, 62)21_Publication in refereed journalpeer-review