New synthetic strategy for chiral 2-oxazolidinones derivatives via rhodium-catalyzed asymmetric hydrogenation

Qingli Wang; Xuefeng Tan; Ziyue Zhu; Xiu-Qin Dong; Xumu Zhang

doi:10.1016/j.tetlet.2015.12.105

New synthetic strategy for chiral 2-oxazolidinones derivatives via rhodium-catalyzed asymmetric hydrogenation

Qingli Wang, Xuefeng Tan, Ziyue Zhu, Xiu-Qin Dong^*, Xumu Zhang

^*Corresponding author for this work

Research output: Journal Publications and Reviews › RGC 21 - Publication in refereed journal › peer-review

22 Citations (Scopus)

Abstract

Asymmetric hydrogenation of 4-substituted cyclic enamido esters catalyzed by a rhodium-TangPhos complex provides an efficient method for the synthesis of chiral 4-substituted oxazolinones with excellent yields and good enantioselectivities. The products are valuable chiral building blocks and the applications as chiral auxiliaries and pharmaceuticals are well-known.

Original language	English
Pages (from-to)	658-662
Journal	Tetrahedron Letters
Volume	57
Issue number	6
DOIs	https://doi.org/10.1016/j.tetlet.2015.12.105
Publication status	Published - 10 Feb 2016
Externally published	Yes

Bibliographical note

Publication details (e.g. title, author(s), publication statuses and dates) are captured on an “AS IS” and “AS AVAILABLE” basis at the time of record harvesting from the data source. Suggestions for further amendments or supplementary information can be sent to [email protected].

Research Keywords

Asymmetric hydrogenation
Chiral 2-oxazolidinones
Enantioselectivity
Phosphine ligand
Rh-catalyzed

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title = "New synthetic strategy for chiral 2-oxazolidinones derivatives via rhodium-catalyzed asymmetric hydrogenation",

abstract = "Asymmetric hydrogenation of 4-substituted cyclic enamido esters catalyzed by a rhodium-TangPhos complex provides an efficient method for the synthesis of chiral 4-substituted oxazolinones with excellent yields and good enantioselectivities. The products are valuable chiral building blocks and the applications as chiral auxiliaries and pharmaceuticals are well-known.",

keywords = "Asymmetric hydrogenation, Chiral 2-oxazolidinones, Enantioselectivity, Phosphine ligand, Rh-catalyzed",

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T1 - New synthetic strategy for chiral 2-oxazolidinones derivatives via rhodium-catalyzed asymmetric hydrogenation

AU - Wang, Qingli

AU - Tan, Xuefeng

AU - Zhu, Ziyue

AU - Dong, Xiu-Qin

AU - Zhang, Xumu

N1 - Publication details (e.g. title, author(s), publication statuses and dates) are captured on an “AS IS” and “AS AVAILABLE” basis at the time of record harvesting from the data source. Suggestions for further amendments or supplementary information can be sent to [email protected].

PY - 2016/2/10

Y1 - 2016/2/10

N2 - Asymmetric hydrogenation of 4-substituted cyclic enamido esters catalyzed by a rhodium-TangPhos complex provides an efficient method for the synthesis of chiral 4-substituted oxazolinones with excellent yields and good enantioselectivities. The products are valuable chiral building blocks and the applications as chiral auxiliaries and pharmaceuticals are well-known.

AB - Asymmetric hydrogenation of 4-substituted cyclic enamido esters catalyzed by a rhodium-TangPhos complex provides an efficient method for the synthesis of chiral 4-substituted oxazolinones with excellent yields and good enantioselectivities. The products are valuable chiral building blocks and the applications as chiral auxiliaries and pharmaceuticals are well-known.

KW - Asymmetric hydrogenation

KW - Chiral 2-oxazolidinones

KW - Enantioselectivity

KW - Phosphine ligand

KW - Rh-catalyzed

UR - http://www.scopus.com/inward/record.url?scp=84955178678&partnerID=8YFLogxK

UR - https://www.scopus.com/record/pubmetrics.uri?eid=2-s2.0-84955178678&origin=recordpage

U2 - 10.1016/j.tetlet.2015.12.105

DO - 10.1016/j.tetlet.2015.12.105

M3 - RGC 21 - Publication in refereed journal

SN - 0040-4039

VL - 57

SP - 658

EP - 662

JO - Tetrahedron Letters

JF - Tetrahedron Letters

IS - 6

ER -

New synthetic strategy for chiral 2-oxazolidinones derivatives via rhodium-catalyzed asymmetric hydrogenation

Abstract

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Research Keywords

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