Neutron scattering in the biological sciences: progress and prospects

Rana Ashkar; Hassina Z. Bilheux; Heliosa Bordallo; Robert Briber; David J. E. Callaway; Xiaolin Cheng; Xiang-Qiang Chu; Joseph E. Curtis; Mark Dadmun; Paul Fenimore; David Fushman; Frank Gabel; Kushol Gupta; Frederick Herberle; Frank Heinrich; Liang Hong; John Katsaras; Zvi Kelman; Eugenia Kharlampieva; Gerald R. Kneller; Andrey Kovalevsky; Susan Krueger; Paul Langan; Raquel Lieberman; Yun Liu; Mathias Losche; Edward Lyman; Yimin Mao; John Marino; Carla Mattos; Flora Meilleur; Peter Moody; Jonathan D. Nickels; William B. O'Dell; Hugh O'Neill; Ursula Perez-Salas; Judith Peters; Loukas Petridis; Alexei P. Sokolov; Christopher Stanley; Norman Wagner; Michael Weinrich; Kevin Weiss; Troy Wymore; Yang Zhang; Jeremy C. Smith

doi:10.1107/S2059798318017503

Neutron scattering in the biological sciences: progress and prospects

Rana Ashkar
, Hassina Z. Bilheux
, Heliosa Bordallo
, Robert Briber
, David J. E. Callaway
, Xiaolin Cheng
, Xiang-Qiang Chu
, Joseph E. Curtis
, Mark Dadmun
, Paul Fenimore
, David Fushman
, Frank Gabel
, Kushol Gupta
, Frederick Herberle
, Frank Heinrich
, Liang Hong
, John Katsaras
, Zvi Kelman
, Eugenia Kharlampieva
, Gerald R. Kneller

Andrey Kovalevsky, Susan Krueger, Paul Langan, Raquel Lieberman, Yun Liu, Mathias Losche, Edward Lyman, Yimin Mao, John Marino, Carla Mattos, Flora Meilleur, Peter Moody, Jonathan D. Nickels, William B. O'Dell, Hugh O'Neill, Ursula Perez-Salas, Judith Peters, Loukas Petridis, Alexei P. Sokolov, Christopher Stanley, Norman Wagner, Michael Weinrich, Kevin Weiss, Troy Wymore, Yang Zhang, Jeremy C. Smith^*

^*Corresponding author for this work

Research output: Journal Publications and Reviews › RGC 21 - Publication in refereed journal › peer-review

70 Citations (Scopus)

Abstract

The scattering of neutrons can be used to provide information on the structure and dynamics of biological systems on multiple length and time scales. Pursuant to a National Science Foundation-funded workshop in February 2018, recent developments in this field are reviewed here, as well as future prospects that can be expected given recent advances in sources, instrumentation and computational power and methods. Crystallography, solution scattering, dynamics, membranes, labeling and imaging are examined. For the extraction of maximum information, the incorporation of judicious specific deuterium labeling, the integration of several types of experiment, and interpretation using high-performance computer simulation models are often found to be particularly powerful.

Original language	English
Pages (from-to)	1129-1168
Journal	Acta Crystallographica Section D: Structural Biology
Volume	74
Issue number	12
DOIs	https://doi.org/10.1107/S2059798318017503
Publication status	Published - 1 Dec 2018
Externally published	Yes

Bibliographical note

Publication details (e.g. title, author(s), publication statuses and dates) are captured on an “AS IS” and “AS AVAILABLE” basis at the time of record harvesting from the data source. Suggestions for further amendments or supplementary information can be sent to [email protected].

Research Keywords

biological systems
neutron scattering
structure and dynamics

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Ashkar, R., Bilheux, H. Z., Bordallo, H., Briber, R., Callaway, D. J. E., Cheng, X., Chu, X.-Q., Curtis, J. E., Dadmun, M., Fenimore, P., Fushman, D., Gabel, F., Gupta, K., Herberle, F., Heinrich, F., Hong, L., Katsaras, J., Kelman, Z., Kharlampieva, E., ... Smith, J. C. (2018). Neutron scattering in the biological sciences: progress and prospects. Acta Crystallographica Section D: Structural Biology, 74(12), 1129-1168. https://doi.org/10.1107/S2059798318017503

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title = "Neutron scattering in the biological sciences: progress and prospects",

abstract = "The scattering of neutrons can be used to provide information on the structure and dynamics of biological systems on multiple length and time scales. Pursuant to a National Science Foundation-funded workshop in February 2018, recent developments in this field are reviewed here, as well as future prospects that can be expected given recent advances in sources, instrumentation and computational power and methods. Crystallography, solution scattering, dynamics, membranes, labeling and imaging are examined. For the extraction of maximum information, the incorporation of judicious specific deuterium labeling, the integration of several types of experiment, and interpretation using high-performance computer simulation models are often found to be particularly powerful.",

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Ashkar, R, Bilheux, HZ, Bordallo, H, Briber, R, Callaway, DJE, Cheng, X, Chu, X-Q, Curtis, JE, Dadmun, M, Fenimore, P, Fushman, D, Gabel, F, Gupta, K, Herberle, F, Heinrich, F, Hong, L, Katsaras, J, Kelman, Z, Kharlampieva, E, Kneller, GR, Kovalevsky, A, Krueger, S, Langan, P, Lieberman, R, Liu, Y, Losche, M, Lyman, E, Mao, Y, Marino, J, Mattos, C, Meilleur, F, Moody, P, Nickels, JD, O'Dell, WB, O'Neill, H, Perez-Salas, U, Peters, J, Petridis, L, Sokolov, AP, Stanley, C, Wagner, N, Weinrich, M, Weiss, K, Wymore, T, Zhang, Y & Smith, JC 2018, 'Neutron scattering in the biological sciences: progress and prospects', Acta Crystallographica Section D: Structural Biology, vol. 74, no. 12, pp. 1129-1168. https://doi.org/10.1107/S2059798318017503

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AU - Ashkar, Rana

AU - Bilheux, Hassina Z.

AU - Bordallo, Heliosa

AU - Briber, Robert

AU - Callaway, David J. E.

AU - Cheng, Xiaolin

AU - Chu, Xiang-Qiang

AU - Curtis, Joseph E.

AU - Dadmun, Mark

AU - Fenimore, Paul

AU - Fushman, David

AU - Gabel, Frank

AU - Gupta, Kushol

AU - Herberle, Frederick

AU - Heinrich, Frank

AU - Hong, Liang

AU - Katsaras, John

AU - Kelman, Zvi

AU - Kharlampieva, Eugenia

AU - Kneller, Gerald R.

AU - Kovalevsky, Andrey

AU - Krueger, Susan

AU - Langan, Paul

AU - Lieberman, Raquel

AU - Liu, Yun

AU - Losche, Mathias

AU - Lyman, Edward

AU - Mao, Yimin

AU - Marino, John

AU - Mattos, Carla

AU - Meilleur, Flora

AU - Moody, Peter

AU - Nickels, Jonathan D.

AU - O'Dell, William B.

AU - O'Neill, Hugh

AU - Perez-Salas, Ursula

AU - Peters, Judith

AU - Petridis, Loukas

AU - Sokolov, Alexei P.

AU - Stanley, Christopher

AU - Wagner, Norman

AU - Weinrich, Michael

AU - Weiss, Kevin

AU - Wymore, Troy

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N2 - The scattering of neutrons can be used to provide information on the structure and dynamics of biological systems on multiple length and time scales. Pursuant to a National Science Foundation-funded workshop in February 2018, recent developments in this field are reviewed here, as well as future prospects that can be expected given recent advances in sources, instrumentation and computational power and methods. Crystallography, solution scattering, dynamics, membranes, labeling and imaging are examined. For the extraction of maximum information, the incorporation of judicious specific deuterium labeling, the integration of several types of experiment, and interpretation using high-performance computer simulation models are often found to be particularly powerful.

AB - The scattering of neutrons can be used to provide information on the structure and dynamics of biological systems on multiple length and time scales. Pursuant to a National Science Foundation-funded workshop in February 2018, recent developments in this field are reviewed here, as well as future prospects that can be expected given recent advances in sources, instrumentation and computational power and methods. Crystallography, solution scattering, dynamics, membranes, labeling and imaging are examined. For the extraction of maximum information, the incorporation of judicious specific deuterium labeling, the integration of several types of experiment, and interpretation using high-performance computer simulation models are often found to be particularly powerful.

KW - biological systems

KW - neutron scattering

KW - structure and dynamics

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DO - 10.1107/S2059798318017503

M3 - RGC 21 - Publication in refereed journal

C2 - 30605130

SN - 2059-7983

VL - 74

SP - 1129

EP - 1168

JO - Acta Crystallographica Section D: Structural Biology

JF - Acta Crystallographica Section D: Structural Biology

IS - 12

ER -

Neutron scattering in the biological sciences: progress and prospects

Abstract

Bibliographical note

Research Keywords

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