Neuropeptide Y Gene × Environment Interaction Predicts Resilience and Positive Future Focus

Yiqun Gan; Yidi Chen; Xiao Han; Nancy Xiaonan Yu; Li Wang

doi:10.1111/aphw.12162

Neuropeptide Y Gene × Environment Interaction Predicts Resilience and Positive Future Focus

Yiqun Gan^*, Yidi Chen, Xiao Han, Nancy Xiaonan Yu, Li Wang

^*Corresponding author for this work

Department of Social and Behavioural Sciences

Research output: Journal Publications and Reviews › RGC 21 - Publication in refereed journal › peer-review

18 Citations (Scopus)

Abstract

Background: The objective of this study was to investigate whether the NPY rs16147 polymorphism interacts with the environment to have an impact on resilience and positive future focus. Methods: In Study 1, 1,140 earthquake survivors were evaluated; self-reported trauma exposure level and resilience were reported. Study 2 included 2,370 company employees and university students; information regarding self-reported early stressful life events and positive future focus were obtained. Results: In both studies, the results showed a significant effect of interaction between the NPY rs16147 polymorphism and the level of stress on resilience. In Study 1, the T allele carriers reported consistent levels of resilience in low, moderate, and high levels of trauma exposure. In Study 2, the T genotype was associated with higher levels of positive future focus following early adversity. Conclusions: Our findings are discussed in light of the differential post-stress growth hypothesis.

Original language	English
Pages (from-to)	438-458
Journal	Applied Psychology: Health and Well-Being
Volume	11
Issue number	3
Online published	13 Jun 2019
DOIs	https://doi.org/10.1111/aphw.12162
Publication status	Published - Nov 2019

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Full text of this publication does not contain sufficient affiliation information. With consent from the author(s) concerned, the Research Unit(s) information for this record is based on the existing academic department affiliation of the author(s).

Research Keywords

differential post-stress growth hypothesis
G×E interaction
NPY rs16147 polymorphism
positive future focus
resilience

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title = "Neuropeptide Y Gene × Environment Interaction Predicts Resilience and Positive Future Focus",

abstract = "Background: The objective of this study was to investigate whether the NPY rs16147 polymorphism interacts with the environment to have an impact on resilience and positive future focus. Methods: In Study 1, 1,140 earthquake survivors were evaluated; self-reported trauma exposure level and resilience were reported. Study 2 included 2,370 company employees and university students; information regarding self-reported early stressful life events and positive future focus were obtained. Results: In both studies, the results showed a significant effect of interaction between the NPY rs16147 polymorphism and the level of stress on resilience. In Study 1, the T allele carriers reported consistent levels of resilience in low, moderate, and high levels of trauma exposure. In Study 2, the T genotype was associated with higher levels of positive future focus following early adversity. Conclusions: Our findings are discussed in light of the differential post-stress growth hypothesis.",

keywords = "differential post-stress growth hypothesis, G×E interaction, NPY rs16147 polymorphism, positive future focus, resilience",

author = "Yiqun Gan and Yidi Chen and Xiao Han and Yu, {Nancy Xiaonan} and Li Wang",

note = "Full text of this publication does not contain sufficient affiliation information. With consent from the author(s) concerned, the Research Unit(s) information for this record is based on the existing academic department affiliation of the author(s).",

year = "2019",

month = nov,

doi = "10.1111/aphw.12162",

language = "English",

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T1 - Neuropeptide Y Gene × Environment Interaction Predicts Resilience and Positive Future Focus

AU - Gan, Yiqun

AU - Chen, Yidi

AU - Han, Xiao

AU - Yu, Nancy Xiaonan

AU - Wang, Li

N1 - Full text of this publication does not contain sufficient affiliation information. With consent from the author(s) concerned, the Research Unit(s) information for this record is based on the existing academic department affiliation of the author(s).

PY - 2019/11

Y1 - 2019/11

N2 - Background: The objective of this study was to investigate whether the NPY rs16147 polymorphism interacts with the environment to have an impact on resilience and positive future focus. Methods: In Study 1, 1,140 earthquake survivors were evaluated; self-reported trauma exposure level and resilience were reported. Study 2 included 2,370 company employees and university students; information regarding self-reported early stressful life events and positive future focus were obtained. Results: In both studies, the results showed a significant effect of interaction between the NPY rs16147 polymorphism and the level of stress on resilience. In Study 1, the T allele carriers reported consistent levels of resilience in low, moderate, and high levels of trauma exposure. In Study 2, the T genotype was associated with higher levels of positive future focus following early adversity. Conclusions: Our findings are discussed in light of the differential post-stress growth hypothesis.

AB - Background: The objective of this study was to investigate whether the NPY rs16147 polymorphism interacts with the environment to have an impact on resilience and positive future focus. Methods: In Study 1, 1,140 earthquake survivors were evaluated; self-reported trauma exposure level and resilience were reported. Study 2 included 2,370 company employees and university students; information regarding self-reported early stressful life events and positive future focus were obtained. Results: In both studies, the results showed a significant effect of interaction between the NPY rs16147 polymorphism and the level of stress on resilience. In Study 1, the T allele carriers reported consistent levels of resilience in low, moderate, and high levels of trauma exposure. In Study 2, the T genotype was associated with higher levels of positive future focus following early adversity. Conclusions: Our findings are discussed in light of the differential post-stress growth hypothesis.

KW - differential post-stress growth hypothesis

KW - G×E interaction

KW - NPY rs16147 polymorphism

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DO - 10.1111/aphw.12162

M3 - RGC 21 - Publication in refereed journal

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EP - 458

JO - Applied Psychology: Health and Well-Being

JF - Applied Psychology: Health and Well-Being

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ER -

Neuropeptide Y Gene × Environment Interaction Predicts Resilience and Positive Future Focus

Abstract

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