Near-Infrared Light-Triggered Lysosome-Targetable Carbon Dots for Photothermal Therapy of Cancer

Research output: Journal Publications and Reviews (RGC: 21, 22, 62)21_Publication in refereed journalpeer-review

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Author(s)

  • Shaojing Zhao
  • Li Yan
  • Mingyue Cao
  • Li Huang
  • Ke Yang
  • Shuilin Wu
  • Minhuan Lan
  • Guangle Niu

Detail(s)

Original languageEnglish
Pages (from-to)53610–53617
Journal / PublicationACS Applied Materials and Interfaces
Volume13
Issue number45
Online published3 Nov 2021
Publication statusPublished - 17 Nov 2021

Abstract

Photothermal therapy (PTT) has inherent advantages in the treatment of hypoxic tumors due to its optically controlled selectivity on tumor ablation and oxygen-independent nature. The subcellular organelle-targeting capability and photothermal conversion efficiency (PCE) at near-infrared (NIR) wavelength are the key parameters in the assessment of the photothermal agent (PTA). Here, we report that carbon dots (CDs) prepared by the hydrothermal treatment of coronene derivatives show a high PCE of 54.7% at 808 nm, which can be attributed to the narrow band gap and the presence of amounts of continuous energy bands on CDs. Moreover, the vibrations in the layered graphite structures of the CDs also increase the rate of nonradiative transition and thus enhance the PCE. Furthermore, the CDs also possess excellent photostability, biocompatibility, and cell penetration capability and could mainly accumulate in the lysosomes. These experiment results have proved that the CDs are suitable as an efficient NIR light-triggered PTA for efficient PTT against cancer.

Research Area(s)

  • band gap, carbon dots, fluorescence imaging, lysosome-targeted, near-infrared, photothermal therapy

Citation Format(s)

Near-Infrared Light-Triggered Lysosome-Targetable Carbon Dots for Photothermal Therapy of Cancer. / Zhao, Shaojing; Yan, Li; Cao, Mingyue; Huang, Li; Yang, Ke; Wu, Shuilin; Lan, Minhuan; Niu, Guangle; Zhang, Wenjun.

In: ACS Applied Materials and Interfaces, Vol. 13, No. 45, 17.11.2021, p. 53610–53617.

Research output: Journal Publications and Reviews (RGC: 21, 22, 62)21_Publication in refereed journalpeer-review