Near-infrared light-triggered drug delivery system based on black phosphorus for in vivo bone regeneration

Xuzhu Wang; Jundong Shao; Mustafa Abd El Raouf; Hanhan Xie; Hao Huang; Huaiyu Wang; Paul K. Chu; Xue-Feng Yu; Yang Yang; AbdelBasit M. AbdEl-Aal; Nefissa H.M. Mekkawy; Richard J. Miron; Yufeng Zhang

doi:10.1016/j.biomaterials.2018.06.039

Author(s)

Xuzhu Wang
Jundong Shao
Mustafa Abd El Raouf
Hanhan Xie
Hao Huang
Huaiyu Wang
Xue-Feng Yu
Yang Yang
AbdelBasit M. AbdEl-Aal
Nefissa H.M. Mekkawy
Richard J. Miron
Yufeng Zhang

Related Research Unit(s)

Detail(s)

Original language	English
Pages (from-to)	164-174
Journal / Publication	Biomaterials
Volume	179
Online published	3 Jul 2018
Publication status	Published - Oct 2018

Link(s)

DOI	DOI https://doi.org/10.1016/j.biomaterials.2018.06.039 Final Published version
	Check@CityULib
Link to Scopus	https://www.scopus.com/record/display.uri?eid=2-s2.0-85053183707&origin=recordpage
Permanent Link	https://scholars.cityu.edu.hk/en/publications/publication(eb993192-746f-4937-b6c4-2d0d87dcf736).html

Abstract

A near-infrared (NIR) light-triggered drug delivery platform is produced by incorporating SrCl₂ and BP nanosheets (BPs) into poly(lactic-co-glycolic acid) (PLGA) for bone regeneration. The fabricated BP-SrCl₂/PLGA microspheres show efficient NIR absorption and photothermal effects due to the BPs. The NIR-triggered release behavior of Sr²⁺ by flawing the PLGA shells is investigated and the microspheres exhibit excellent cell viability and biodegradability. Implantation of the BP-SrCl₂/PLGA microspheres into a rat femoral defect demonstrates good tissue compatibility and excellent bone regeneration capacity under NIR light irradiation. Our study indicates that local release of Sr²⁺ at optimal time periods controlled by NIR irradiation improves bone regeneration significantly and this NIR-triggered drug delivery system composed of BPs is suitable for therapies requiring precise control at specific time.

Research Area(s)

Black phosphorus, Photothermal effect, 2D materials, Bone regeneration, Near-infrared, STRONTIUM RANELATE, BIOMEDICAL APPLICATIONS, MAGNETIC NANOPARTICLES, PHOTOTHERMAL THERAPY, CHEMICAL-COMPOSITION, VERTEBRAL FRACTURES, CONTROLLED-RELEASE, OSTEOPOROTIC BONE, CANCER-THERAPY, BASIC SCIENCE

Citation Format(s)

[ RIS ] [ BibTeX ]

Near-infrared light-triggered drug delivery system based on black phosphorus for in vivo bone regeneration. / Wang, Xuzhu; Shao, Jundong; Abd El Raouf, Mustafa et al.

In: Biomaterials, Vol. 179, 10.2018, p. 164-174.

Research output: Journal Publications and Reviews (RGC: 21, 22, 62) › 21_Publication in refereed journal › peer-review

Wang, X, Shao, J, Abd El Raouf, M, Xie, H, Huang, H, Wang, H, Chu, PK, Yu, X-F, Yang, Y, AbdEl-Aal, AM, Mekkawy, NHM, Miron, RJ & Zhang, Y 2018, 'Near-infrared light-triggered drug delivery system based on black phosphorus for in vivo bone regeneration', Biomaterials, vol. 179, pp. 164-174. https://doi.org/10.1016/j.biomaterials.2018.06.039

Wang, X., Shao, J., Abd El Raouf, M., Xie, H., Huang, H., Wang, H., Chu, P. K., Yu, X-F., Yang, Y., AbdEl-Aal, A. M., Mekkawy, N. H. M., Miron, R. J., & Zhang, Y. (2018). Near-infrared light-triggered drug delivery system based on black phosphorus for in vivo bone regeneration. Biomaterials, 179, 164-174. https://doi.org/10.1016/j.biomaterials.2018.06.039

Wang X, Shao J, Abd El Raouf M, Xie H, Huang H, Wang H et al. Near-infrared light-triggered drug delivery system based on black phosphorus for in vivo bone regeneration. Biomaterials. 2018 Oct;179:164-174. Epub 2018 Jul 3. doi: 10.1016/j.biomaterials.2018.06.039

Wang, Xuzhu ; Shao, Jundong ; Abd El Raouf, Mustafa et al. / Near-infrared light-triggered drug delivery system based on black phosphorus for in vivo bone regeneration. In: Biomaterials. 2018 ; Vol. 179. pp. 164-174.