Near-infrared light-triggered drug delivery system based on black phosphorus for in vivo bone regeneration
Research output: Journal Publications and Reviews (RGC: 21, 22, 62) › 21_Publication in refereed journal › peer-review
Author(s)
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Detail(s)
Original language | English |
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Pages (from-to) | 164-174 |
Journal / Publication | Biomaterials |
Volume | 179 |
Online published | 3 Jul 2018 |
Publication status | Published - Oct 2018 |
Link(s)
Abstract
A near-infrared (NIR) light-triggered drug delivery platform is produced by incorporating SrCl2 and BP nanosheets (BPs) into poly(lactic-co-glycolic acid) (PLGA) for bone regeneration. The fabricated BP-SrCl2/PLGA microspheres show efficient NIR absorption and photothermal effects due to the BPs. The NIR-triggered release behavior of Sr2+ by flawing the PLGA shells is investigated and the microspheres exhibit excellent cell viability and biodegradability. Implantation of the BP-SrCl2/PLGA microspheres into a rat femoral defect demonstrates good tissue compatibility and excellent bone regeneration capacity under NIR light irradiation. Our study indicates that local release of Sr2+ at optimal time periods controlled by NIR irradiation improves bone regeneration significantly and this NIR-triggered drug delivery system composed of BPs is suitable for therapies requiring precise control at specific time.
Research Area(s)
- Black phosphorus, Photothermal effect, 2D materials, Bone regeneration, Near-infrared, STRONTIUM RANELATE, BIOMEDICAL APPLICATIONS, MAGNETIC NANOPARTICLES, PHOTOTHERMAL THERAPY, CHEMICAL-COMPOSITION, VERTEBRAL FRACTURES, CONTROLLED-RELEASE, OSTEOPOROTIC BONE, CANCER-THERAPY, BASIC SCIENCE
Citation Format(s)
Near-infrared light-triggered drug delivery system based on black phosphorus for in vivo bone regeneration. / Wang, Xuzhu; Shao, Jundong; Abd El Raouf, Mustafa et al.
In: Biomaterials, Vol. 179, 10.2018, p. 164-174.Research output: Journal Publications and Reviews (RGC: 21, 22, 62) › 21_Publication in refereed journal › peer-review