Near-infrared light-triggered drug delivery system based on black phosphorus for in vivo bone regeneration

Research output: Journal Publications and Reviews (RGC: 21, 22, 62)21_Publication in refereed journal

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Author(s)

  • Xuzhu Wang
  • Jundong Shao
  • Mustafa Abd El Raouf
  • Hanhan Xie
  • Hao Huang
  • Huaiyu Wang
  • Xue-Feng Yu
  • Yang Yang
  • AbdelBasit M. AbdEl-Aal
  • Nefissa H.M. Mekkawy
  • Richard J. Miron
  • Yufeng Zhang

Detail(s)

Original languageEnglish
Pages (from-to)164-174
Journal / PublicationBiomaterials
Volume179
Online published3 Jul 2018
Publication statusPublished - Oct 2018

Abstract

A near-infrared (NIR) light-triggered drug delivery platform is produced by incorporating SrCl2 and BP nanosheets (BPs) into poly(lactic-co-glycolic acid) (PLGA) for bone regeneration. The fabricated BP-SrCl2/PLGA microspheres show efficient NIR absorption and photothermal effects due to the BPs. The NIR-triggered release behavior of Sr2+ by flawing the PLGA shells is investigated and the microspheres exhibit excellent cell viability and biodegradability. Implantation of the BP-SrCl2/PLGA microspheres into a rat femoral defect demonstrates good tissue compatibility and excellent bone regeneration capacity under NIR light irradiation. Our study indicates that local release of Sr2+ at optimal time periods controlled by NIR irradiation improves bone regeneration significantly and this NIR-triggered drug delivery system composed of BPs is suitable for therapies requiring precise control at specific time.

Research Area(s)

  • Black phosphorus, Photothermal effect, 2D materials, Bone regeneration, Near-infrared, STRONTIUM RANELATE, BIOMEDICAL APPLICATIONS, MAGNETIC NANOPARTICLES, PHOTOTHERMAL THERAPY, CHEMICAL-COMPOSITION, VERTEBRAL FRACTURES, CONTROLLED-RELEASE, OSTEOPOROTIC BONE, CANCER-THERAPY, BASIC SCIENCE

Citation Format(s)

Near-infrared light-triggered drug delivery system based on black phosphorus for in vivo bone regeneration. / Wang, Xuzhu; Shao, Jundong; Abd El Raouf, Mustafa; Xie, Hanhan; Huang, Hao; Wang, Huaiyu; Chu, Paul K.; Yu, Xue-Feng; Yang, Yang; AbdEl-Aal, AbdelBasit M.; Mekkawy, Nefissa H.M.; Miron, Richard J.; Zhang, Yufeng.

In: Biomaterials, Vol. 179, 10.2018, p. 164-174.

Research output: Journal Publications and Reviews (RGC: 21, 22, 62)21_Publication in refereed journal