Near-infrared light II - assisted rapid biofilm elimination platform for bone implants at mild temperature

Research output: Journal Publications and Reviews (RGC: 21, 22, 62)21_Publication in refereed journalpeer-review

8 Scopus Citations
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Author(s)

  • Guannan Zhang
  • Yongqiang Yang
  • Jing Shi
  • Xiaohong Yao
  • Weiyi Chen
  • Xiaochun Wei
  • Xiangyu Zhang

Detail(s)

Original languageEnglish
Article number120634
Journal / PublicationBiomaterials
Volume269
Online published30 Dec 2020
Publication statusPublished - Feb 2021

Abstract

Light-triggered therapy is a prospective method to combat implant-associated infection but near-infrared I (NIR-I) light has insufficient penetrating ability in tissues and local hyperthermia induced by the photothermal treatment may destroy surrounding healthy tissues. Herein, a near-infrared II (NIR-II) phototherapy system composed of upconversion elements doped titanium dioxide nanorods (TiO2 NRs)/curcumin (Cur)/hyaluronic acid (HA)/bone morphogenetic protein-2 (BMP-2) is designed for biomedical titanium and demonstrated to overcome the above hurdles simultaneously. Incorporation of F, Yb, and Ho not only improves the photocatalytic ability, but also renders the implants with the upconversion capability, so that the NRs can generate enough reactive oxygen species (ROS) when irradiated by the NIR-II laser. Furthermore, the combined actions of quorum sensing inhibitors, ROS, and physical puncture by NRs eliminate Staphylococcus aureus biofilms on titanium rapidly at a mild temperature of 45 °C by only requiring irradiation with the 1060 nm laser for only 15 min in vitro and in vivo. The presence of Cur mitigates the immune response and BMP-2 improves osteogenic differentiation, thus accelerating new bone formation. This low-temperature NIR-II light-triggered antibacterial platform has large potential in combating deep-tissue infection in clinical applications.

Research Area(s)

  • Anti-Biofilm, Implants, Osseointegration, Phototherapy, Second near-infrared laser

Citation Format(s)

Near-infrared light II - assisted rapid biofilm elimination platform for bone implants at mild temperature. / Zhang, Guannan; Yang, Yongqiang; Shi, Jing; Yao, Xiaohong; Chen, Weiyi; Wei, Xiaochun; Zhang, Xiangyu; Chu, Paul K.

In: Biomaterials, Vol. 269, 120634, 02.2021.

Research output: Journal Publications and Reviews (RGC: 21, 22, 62)21_Publication in refereed journalpeer-review