Near-infrared light control of bone regeneration with biodegradable photothermal osteoimplant

Research output: Journal Publications and Reviews (RGC: 21, 22, 62)21_Publication in refereed journal

25 Scopus Citations
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Author(s)

  • Liping Tong
  • Qing Liao
  • Yuetao Zhao
  • Hao Huang
  • Wei Zhang
  • Xiaoyong Gao
  • Wei Wei
  • Min Guan
  • Huaiyu Wang

Detail(s)

Original languageEnglish
Pages (from-to)1-11
Journal / PublicationBiomaterials
Volume193
Online published10 Dec 2018
Publication statusPublished - Feb 2019

Abstract

Mild heat stimulation can promote the restoration of bone defects but unfortunately, the delivery of exo-hyperthermy into human body is not efficient enough. In this study, mild heat-induced osteogenesis with high efficacy is demonstrated on an osteoimplant composed of black phosphorus nanosheets and poly(lactic-co-glycolic acid) (BPs@PLGA) with the participation of near-infrared (NIR) light irradiation. BPs@PLGA with only 0.2 wt% BPs show the highly-efficient NIR photothermal response even when being covered by a biological tissue as thick as 7 mm. In addition, this composite is completely biodegradable and the final degradation products are harmless H2O, CO2 and PO4 3− which can serve as necessary bone ingredient. The BPs@PLGA specimen mediated by low intensity and periodic NIR irradiation can effectively up-regulate the expressions of heat shock proteins and finally promote osteogenesis in vitro and in vivo. Boasting good biodegradability and NIR-mediated osteogenetic performances, the BPs@PLGA implant has great potential in orthopedic applications and this study provides new insights into the design and fabrication of new-style osteoimplants which can be remotely controlled.

Research Area(s)

  • Black phosphorus, Bone regeneration, Photothermal therapy, Tissue engineering

Citation Format(s)

Near-infrared light control of bone regeneration with biodegradable photothermal osteoimplant. / Tong, Liping; Liao, Qing; Zhao, Yuetao; Huang, Hao; Gao, Ang; Zhang, Wei; Gao, Xiaoyong; Wei, Wei; Guan, Min; Chu, Paul K.; Wang, Huaiyu.

In: Biomaterials, Vol. 193, 02.2019, p. 1-11.

Research output: Journal Publications and Reviews (RGC: 21, 22, 62)21_Publication in refereed journal