Near-Infrared Hypocrellin Derivatives for Synergistic Photodynamic and Photothermal Therapy

Research output: Journal Publications and Reviews (RGC: 21, 22, 62)21_Publication in refereed journalpeer-review

4 Scopus Citations
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Author(s)

  • Ying Ding
  • Weimin Liu
  • Jiasheng Wu
  • Xiuli Zheng
  • Jiechao Ge
  • Haohui Ren
  • Pengfei Wang

Detail(s)

Original languageEnglish
Article number3462-3468
Journal / PublicationChemistry - An Asian Journal
Volume15
Issue number21
Online published10 Sep 2020
Publication statusPublished - 2 Nov 2020

Abstract

Hypocrellin B (HB) derived from naturally produced hypocrellins has attracted considerable attention in photodynamic therapy (PDT) because of its excellent photosensitive properties. However, the weak absorption within a “phototherapy window” (600–900 nm) and poor water solubility of HB have limited its clinical application. In this study, two HB derivatives (i. e., HE and HF) were designed and synthesized for the first time by introducing two different substituent groups into the HB structure. The obtained derivatives showed a broad absorption band covering the near-infrared (NIR) region, NIR emission (peaked at 805 nm), and singlet oxygen quantum yields of 0.27/0.31. HE-PEG-NPs were also prepared using 2-distearoyl-sn-glycero-3-phosphoethanolamine-N-[methoxy(polyethyleneglycol)-2000] (DSPE-mPEG2000) to achieve excellent dispersion in water and further explored their practical applications. HE-PEG-NPs not only retained their 1O2-generating ability, but also exhibited a photothermal conversion efficiency of 25.9%. In vitro and in vivo therapeutic results revealed that the synergetic effect of HE-PEG-NPs on PDT and photothermal therapy (PTT) could achieve a good performance. Therefore, HE-PEG-NPs could be regarded as a promising phototheranostic agent.

Research Area(s)

  • Hypocrellin derivatives, Photodynamic therapy, Photothermal therapy, Synergistic effect

Citation Format(s)

Near-Infrared Hypocrellin Derivatives for Synergistic Photodynamic and Photothermal Therapy. / Ding, Ying; Liu, Weimin; Wu, Jiasheng; Zheng, Xiuli; Ge, Jiechao; Ren, Haohui; Zhang, Wenjun; Lee, Chun-Sing; Wang, Pengfei.

In: Chemistry - An Asian Journal, Vol. 15, No. 21, 3462-3468, 02.11.2020.

Research output: Journal Publications and Reviews (RGC: 21, 22, 62)21_Publication in refereed journalpeer-review