Nasal Lymphoma with Low Mitotic Index in Three Cats Treated with Chlorambucil and Prednisolone

Karen W. L. Ng; Julia A. Beatty; May P. Y. Tse; Antonio Giuliano

doi:10.3390/vetsci9090472

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Detail(s)

Original language	English
Article number	472
Journal / Publication	Veterinary Sciences
Volume	9
Issue number	9
Online published	1 Sept 2022
Publication status	Published - Sept 2022

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DOI	DOI https://doi.org/10.3390/vetsci9090472 Final Published version
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Attachment(s)	Documents 116365635.pdf Final Published version, 7.24 MB, PDF Publisher's Copyright Statement This full text is made available under CC-BY 4.0. https://creativecommons.org/licenses/by/4.0/
Link to Scopus	https://www.scopus.com/record/display.uri?eid=2-s2.0-85138526333&origin=recordpage
Permanent Link	https://scholars.cityu.edu.hk/en/publications/publication(b242576c-fe70-492d-86c4-784319bd8dd7).html

Abstract

Lymphoma is the most common tumor of the nasal cavity in cats. Commonly used treatment modalities are radiotherapy and chemotherapy, or both. Typical chemotherapy protocols used in cats with nasal lymphoma are COP (cyclophosphamide, vincristine prednisolone) and CHOP (cyclophosphamide, doxorubicin, vincristine and prednisolone). Thus far, the use of single-agent chlorambucil in nasal lymphoma has been evaluated in a single case report. We report a case series of three cats with B cell nasal lymphoma, two cats with intermediate cell, and one large cell, all with a low mitotic index (MI) of less than 5 mitotic figures per ×400 field, treated with chlorambucil and prednisolone. Two of the cases achieved a long disease-free interval, while the one with the highest MI did not. Protocols using chlorambucil and prednisolone may have potential as a first-line therapy for feline nasal lymphoma cases with a very low mitotic index.

© 2022 by the authors.