Nanovesicles derived from iron oxide nanoparticles-incorporated mesenchymal stem cells for cardiac repair

Research output: Journal Publications and ReviewsRGC 21 - Publication in refereed journalpeer-review

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Author(s)

  • Ju-Ro Lee
  • Bong-Woo Park
  • Jonghoon Kim
  • Yeon Woong Choo
  • Han Young Kim
  • Jeong-Kee Yoon
  • Hyeok Kim
  • Ji-Won Hwang
  • Mikyung Kang
  • Sung Pil Kwon
  • Seuk Young Song
  • In Ok Ko
  • Ji-Ae Park
  • Taeghwan Hyeon
  • Hun-Jun Park
  • Byung-Soo Kim

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Detail(s)

Original languageEnglish
Article numbereaaz0952
Journal / PublicationScience Advances
Volume6
Issue number18
Online published1 May 2020
Publication statusPublished - 2020

Link(s)

Abstract

Because of poor engraftment and safety concerns regarding mesenchymal stem cell (MSC) therapy, MSC-derived exosomes have emerged as an alternative cell-free therapy for myocardial infarction (MI). However, the diffusion of exosomes out of the infarcted heart following injection and the low productivity limit the potential of clinical applications. Here, we developed exosome-mimetic extracellular nanovesicles (NVs) derived from iron oxide nanoparticles (IONPs)-incorporated MSCs (IONP-MSCs). The retention of injected IONP-MSC-derived NVs (IONP-NVs) within the infarcted heart was markedly augmented by magnetic guidance. Furthermore, IONPs significantly increased the levels of therapeutic molecules in IONP-MSCs and IONP-NVs, which can reduce the concern of low exosome productivity. The injection of IONP-NVs into the infarcted heart and magnetic guidance induced an early shift from the inflammation phase to the reparative phase, reduced apoptosis and fibrosis, and enhanced angiogenesis and cardiac function recovery. This approach can enhance the therapeutic potency of an MSC-derived NV therapy.

Citation Format(s)

Nanovesicles derived from iron oxide nanoparticles-incorporated mesenchymal stem cells for cardiac repair. / Lee, Ju-Ro; Park, Bong-Woo; Kim, Jonghoon et al.
In: Science Advances, Vol. 6, No. 18, eaaz0952, 2020.

Research output: Journal Publications and ReviewsRGC 21 - Publication in refereed journalpeer-review

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