Nanoprobes-Assisted Multichannel NIR-II Fluorescence Imaging-Guided Resection and Photothermal Ablation of Lymph Nodes

Research output: Journal Publications and Reviews (RGC: 21, 22, 62)21_Publication in refereed journalpeer-review

8 Scopus Citations
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Author(s)

  • Xiaoxiao Fan
  • Yirun Li
  • Zhe Feng
  • Guoqiao Chen
  • Jing Zhou
  • And 5 others
  • Mubin He
  • Lan Wu
  • Shengliang Li
  • Jun Qian
  • Hui Lin

Detail(s)

Original languageEnglish
Article number2003972
Journal / PublicationAdvanced Science
Volume8
Issue number9
Online published15 Feb 2021
Publication statusPublished - 5 May 2021

Link(s)

Abstract

Lymph node metastasis is a major metastatic route of cancer and significantly influences the prognosis of cancer patients. Radical lymphadenectomy is crucial for a successful surgery. However, iatrogenic normal organ injury during lymphadenectomy is a troublesome complication. Here, this paper reports a kind of organic nanoprobes (IDSe-IC2F nanoparticles (NPs)) with excellent second near-infrared (NIR-II) fluorescence and photothermal properties. IDSe-IC2F NPs can effectively label lymph nodes and helped achieve high-contrast lymphatic imaging. More importantly, by jointly using IDSe-IC2F nanoparticles and other kinds of nanoparticles with different excitation/emission properties, a multichannel NIR-II fluorescence imaging modality and imaging-guided lymphadenectomy is proposed. With the help of this navigation system, the iatrogenic injury can be largely avoided. In addition, NIR-II fluorescence imaging-guided photothermal treatment (“hot” strategy) can ablate those metastatic lymph nodes which are difficult to deal with during resection (“cold” strategy). Nanoprobes-assisted and multichannel NIR-II fluorescence imaging-guided “cold” and “hot” treatment strategy provides a general new basis for the future precision surgery.

Research Area(s)

  • imaging-guided, lymphadenectomy, multichannel, nanoprobes, NIR-II fluorescence imaging, photothermal ablation

Citation Format(s)

Nanoprobes-Assisted Multichannel NIR-II Fluorescence Imaging-Guided Resection and Photothermal Ablation of Lymph Nodes. / Fan, Xiaoxiao; Li, Yirun; Feng, Zhe; Chen, Guoqiao; Zhou, Jing; He, Mubin; Wu, Lan; Li, Shengliang; Qian, Jun; Lin, Hui.

In: Advanced Science, Vol. 8, No. 9, 2003972, 05.05.2021.

Research output: Journal Publications and Reviews (RGC: 21, 22, 62)21_Publication in refereed journalpeer-review

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