Nanoprobes-Assisted Multichannel NIR-II Fluorescence Imaging-Guided Resection and Photothermal Ablation of Lymph Nodes
Research output: Journal Publications and Reviews › RGC 21 - Publication in refereed journal › peer-review
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Detail(s)
Original language | English |
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Article number | 2003972 |
Journal / Publication | Advanced Science |
Volume | 8 |
Issue number | 9 |
Online published | 15 Feb 2021 |
Publication status | Published - 5 May 2021 |
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DOI | DOI |
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Attachment(s) | Documents
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Link to Scopus | https://www.scopus.com/record/display.uri?eid=2-s2.0-85100880963&origin=recordpage |
Permanent Link | https://scholars.cityu.edu.hk/en/publications/publication(00e82b16-620c-4835-9bb8-22ee62326762).html |
Abstract
Lymph node metastasis is a major metastatic route of cancer and significantly influences the prognosis of cancer patients. Radical lymphadenectomy is crucial for a successful surgery. However, iatrogenic normal organ injury during lymphadenectomy is a troublesome complication. Here, this paper reports a kind of organic nanoprobes (IDSe-IC2F nanoparticles (NPs)) with excellent second near-infrared (NIR-II) fluorescence and photothermal properties. IDSe-IC2F NPs can effectively label lymph nodes and helped achieve high-contrast lymphatic imaging. More importantly, by jointly using IDSe-IC2F nanoparticles and other kinds of nanoparticles with different excitation/emission properties, a multichannel NIR-II fluorescence imaging modality and imaging-guided lymphadenectomy is proposed. With the help of this navigation system, the iatrogenic injury can be largely avoided. In addition, NIR-II fluorescence imaging-guided photothermal treatment (“hot” strategy) can ablate those metastatic lymph nodes which are difficult to deal with during resection (“cold” strategy). Nanoprobes-assisted and multichannel NIR-II fluorescence imaging-guided “cold” and “hot” treatment strategy provides a general new basis for the future precision surgery.
Research Area(s)
- imaging-guided, lymphadenectomy, multichannel, nanoprobes, NIR-II fluorescence imaging, photothermal ablation
Citation Format(s)
Nanoprobes-Assisted Multichannel NIR-II Fluorescence Imaging-Guided Resection and Photothermal Ablation of Lymph Nodes. / Fan, Xiaoxiao; Li, Yirun; Feng, Zhe et al.
In: Advanced Science, Vol. 8, No. 9, 2003972, 05.05.2021.
In: Advanced Science, Vol. 8, No. 9, 2003972, 05.05.2021.
Research output: Journal Publications and Reviews › RGC 21 - Publication in refereed journal › peer-review
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