Nanoparticle-on-chip: A CMOS DNA analyzer

Yi Tian; Derek Ho

doi:10.1109/BioCAS.2016.7833865

Nanoparticle-on-chip: A CMOS DNA analyzer

Yi Tian
, Derek Ho^*

^*Corresponding author for this work

Research output: Chapters, Conference Papers, Creative and Literary Works › RGC 32 - Refereed conference paper (with host publication) › peer-review

Abstract

Nanoparticles can be utilized as powerful molecular probes for analyzing a large variety of chemical and biological processes. However, their full integration with mainstream, volume-production complementary metal-oxide-semiconductor (CMOS) technologies is still in its infancy. In this paper, we present a DNA analysis micro-system integrating a nanoparticle-labeled bioassay, thin-film optics, microfluidics, and a CMOS chip. This nanoparticle-on-chip quantifies concentrations of E. coli bacteria and neural muscular atrophy disease DNA strands down to the pmol level.

Original language	English
Title of host publication	Proceedings - 2016 IEEE Biomedical Circuits and Systems Conference, BioCAS 2016
Publisher	IEEE
Pages	596-599
ISBN (Print)	9781509029594
DOIs	https://doi.org/10.1109/BioCAS.2016.7833865
Publication status	Published - 25 Jan 2017
Event	12th IEEE Biomedical Circuits and Systems Conference, BioCAS 2016 - Shanghai, China Duration: 17 Oct 2016 → 19 Oct 2016

Conference

Conference	12th IEEE Biomedical Circuits and Systems Conference, BioCAS 2016
Place	China
City	Shanghai
Period	17/10/16 → 19/10/16

Research Keywords

CMOS
DNA
microfluidics
microsystem
nanoparticle
thin-film

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@inproceedings{aed5c949eae94faa8ca90ab3a4bcc8f9,

title = "Nanoparticle-on-chip: A CMOS DNA analyzer",

abstract = "Nanoparticles can be utilized as powerful molecular probes for analyzing a large variety of chemical and biological processes. However, their full integration with mainstream, volume-production complementary metal-oxide-semiconductor (CMOS) technologies is still in its infancy. In this paper, we present a DNA analysis micro-system integrating a nanoparticle-labeled bioassay, thin-film optics, microfluidics, and a CMOS chip. This nanoparticle-on-chip quantifies concentrations of E. coli bacteria and neural muscular atrophy disease DNA strands down to the pmol level.",

keywords = "CMOS, DNA, microfluidics, microsystem, nanoparticle, thin-film",

author = "Yi Tian and Derek Ho",

year = "2017",

month = jan,

day = "25",

doi = "10.1109/BioCAS.2016.7833865",

language = "English",

isbn = "9781509029594",

pages = "596--599",

booktitle = "Proceedings - 2016 IEEE Biomedical Circuits and Systems Conference, BioCAS 2016",

publisher = "IEEE",

address = "United States",

note = "12th IEEE Biomedical Circuits and Systems Conference, BioCAS 2016 ; Conference date: 17-10-2016 Through 19-10-2016",

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TY - GEN

T1 - Nanoparticle-on-chip

T2 - 12th IEEE Biomedical Circuits and Systems Conference, BioCAS 2016

AU - Tian, Yi

AU - Ho, Derek

PY - 2017/1/25

Y1 - 2017/1/25

N2 - Nanoparticles can be utilized as powerful molecular probes for analyzing a large variety of chemical and biological processes. However, their full integration with mainstream, volume-production complementary metal-oxide-semiconductor (CMOS) technologies is still in its infancy. In this paper, we present a DNA analysis micro-system integrating a nanoparticle-labeled bioassay, thin-film optics, microfluidics, and a CMOS chip. This nanoparticle-on-chip quantifies concentrations of E. coli bacteria and neural muscular atrophy disease DNA strands down to the pmol level.

AB - Nanoparticles can be utilized as powerful molecular probes for analyzing a large variety of chemical and biological processes. However, their full integration with mainstream, volume-production complementary metal-oxide-semiconductor (CMOS) technologies is still in its infancy. In this paper, we present a DNA analysis micro-system integrating a nanoparticle-labeled bioassay, thin-film optics, microfluidics, and a CMOS chip. This nanoparticle-on-chip quantifies concentrations of E. coli bacteria and neural muscular atrophy disease DNA strands down to the pmol level.

KW - CMOS

KW - DNA

KW - microfluidics

KW - microsystem

KW - nanoparticle

KW - thin-film

UR - https://www.scopus.com/pages/publications/85014189053

UR - https://www.scopus.com/record/pubmetrics.uri?eid=2-s2.0-85014189053&origin=recordpage

U2 - 10.1109/BioCAS.2016.7833865

DO - 10.1109/BioCAS.2016.7833865

M3 - RGC 32 - Refereed conference paper (with host publication)

SN - 9781509029594

SP - 596

EP - 599

BT - Proceedings - 2016 IEEE Biomedical Circuits and Systems Conference, BioCAS 2016

PB - IEEE

Y2 - 17 October 2016 through 19 October 2016

ER -

Nanoparticle-on-chip: A CMOS DNA analyzer

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