MXene-Based Aptameric Fluorosensor for Sensitive and Rapid Detection of COVID-19

Research output: Journal Publications and ReviewsRGC 21 - Publication in refereed journalpeer-review

21 Scopus Citations
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Author(s)

  • Yao Luo
  • Xin Jiang
  • Chen Shen
  • Mei Li
  • Zhenzhen Zhao
  • Mengyuan Lv
  • Shengjun Sun
  • Xuping Sun
  • Binwu Ying

Detail(s)

Original languageEnglish
Article number2301146
Journal / PublicationSmall
Volume19
Issue number23
Online published6 Mar 2023
Publication statusPublished - 7 Jun 2023

Abstract

The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)-caused COVID-19 pandemic has rapidly escalated into the largest global health emergency, which pushes to develop detection kits for the detection of COVID-19 with high sensitivity, specificity, and fast analysis. Here, aptamer-functionalized MXene nanosheet is demonstrated as a novel bionanosensor that detects COVID-19. Upon binding to the spike receptor binding domain of SARS-CoV-2, the aptamer probe is released from MXene surface restoring the quenched fluorescence. The performances of the fluorosensor are evaluated using antigen protein, cultured virus, and swab specimens from COVID-19 patients. It is evidenced that this sensor can detect SARS-CoV-2 spike protein at final concentration of 38.9 fg mL−1 and SARS-CoV-2 pseudovirus (limit of detection: 7.2 copies) within 30 min. Its application for clinical samples analysis is also demonstrated successfully. This work offers an effective sensing platform for sensitive and rapid detection of COVID-19 with high specificity. © 2023 Wiley-VCH GmbH.

Research Area(s)

  • cellular imaging, COVID-19, fluorosensors, MXene nanosheets, spike proteins

Citation Format(s)

MXene-Based Aptameric Fluorosensor for Sensitive and Rapid Detection of COVID-19. / Luo, Yao; Jiang, Xin; Zhang, Rong et al.
In: Small, Vol. 19, No. 23, 2301146, 07.06.2023.

Research output: Journal Publications and ReviewsRGC 21 - Publication in refereed journalpeer-review