Mutational Pattern in Multiple Pulmonary Nodules Are Associated With Early Stage Lung Adenocarcinoma

Research output: Journal Publications and Reviews (RGC: 21, 22, 62)21_Publication in refereed journalpeer-review

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Author(s)

  • Shao-wei Dong
  • Rong Li
  • Zhiqiang Cheng
  • Dong-cheng Liu
  • Jinquan Xia
  • And 14 others
  • Jing Xu
  • Shixuan Li
  • Jian Wang
  • Yongjian Yue
  • Yingrui Fan
  • Yundi Cao
  • Lingyun Dai
  • Jigang Wang
  • Pan Zhao
  • Xin Wang
  • Zhangang Xiao
  • Chen Qiu
  • Guang-suo Wang
  • Chang Zou

Related Research Unit(s)

Detail(s)

Original languageEnglish
Article number571521
Journal / PublicationFrontiers in Oncology
Volume10
Online published19 Feb 2021
Publication statusPublished - Feb 2021

Link(s)

Abstract

The clinical significance of mutation in multiple pulmonary nodules is largely limited by single gene mutation-directed analysis and lack of validation of gene expression profiles. New analytic strategy is urgently needed for comprehensive understanding of genomic data in multiple pulmonary nodules. In this study, we performed whole exome sequencing in 16 multiple lung nodules and 5 adjacent normal tissues from 4 patients with multiple pulmonary nodules and decoded the mutation information from a perspective of cellular functions and signaling pathways. Mutated genes as well as mutation patterns shared in more than two lesions were identified and characterized. We found that the number of mutations or mutated genes and the extent of protein structural changes caused by different mutations is positively correlated with the degree of malignancy. Moreover, the mutated genes in the nodules are associated with the molecular functions or signaling pathways related to cell proliferation and survival. We showed a developing pattern of quantity (the number of mutations/mutated genes) and quality (the extent of protein structural changes) in multiple pulmonary nodules. The mutation and mutated genes in multiple pulmonary nodules are associated with cell proliferation and survival related signaling pathways. This study provides a new perspective for comprehension of genomic mutational data and might shed new light on deciphering molecular evolution of early stage lung adenocarcinoma.

Research Area(s)

  • pulmonary nodules, whole-exome sequencing, mutation, functional analysis, pathway analysis

Citation Format(s)

Mutational Pattern in Multiple Pulmonary Nodules Are Associated With Early Stage Lung Adenocarcinoma. / Dong, Shao-wei; Li, Rong; Cheng, Zhiqiang; Liu, Dong-cheng; Xia, Jinquan; Xu, Jing; Li, Shixuan; Wang, Jian; Yue, Yongjian; Fan, Yingrui; Cao, Yundi; Dai, Lingyun; Wang, Jigang; Zhao, Pan; Wang, Xin; Xiao, Zhangang; Qiu, Chen; Wang, Guang-suo; Zou, Chang.

In: Frontiers in Oncology, Vol. 10, 571521, 02.2021.

Research output: Journal Publications and Reviews (RGC: 21, 22, 62)21_Publication in refereed journalpeer-review

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