Multi-Task Learning for Efficient Diagnosis of ASD and ADHD using Resting-State fMRI data

Research output: Conference Papers (RGC: 31A, 31B, 32, 33)32_Refereed conference paper (no ISBN/ISSN)

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Detail(s)

Original languageEnglish
Publication statusPublished - 20 Jul 2020

Conference

Title2020 International Joint Conference on Neural Networks (IJCNN 2020)
PlaceUnited Kingdom
CityGlasgow
Period19 - 24 July 2020

Abstract

Increasing mental disorders have emerged as an urgent public health concern such as autism spectrum disorder (ASD) and attention deficit hyperactivity disorder (ADHD). Related mental disorders may share high overlap in clinical symptoms. Therefore, their diagnosis can be challenging to merely rely on the observation of cognitive phenotypes and behavioral manifestations. Unfortunately, there is no additional support of biochemical markers, laboratory tests, or neuroimaging analysis, which can be used as a diagnostic gold standard currently. Over the past decades, resting-state functional magnetic resonance imaging (rs-fMRI) has been considered as one of the most promising modality to capture the intrinsic neural activation patterns between regions in the brain. In this work, we focus on ASD and ADHD due to their high prevalence and relevance with the aim to exploit the multi-task learning (MTL) paradigm for their diagnosis. To the best of our knowledge, this is the first time to make use of the disease-specific heterogeneities for the MTL classification of ASD and ADHD via rs-fMRI signal. We propose a novel graph-based feature selection method to filter out irrelevant functional connectivity features. Then an efficient structure of multi-gate mixture-of-experts (MMoE) is applied to the MTL classification framework. Finally, the experiment results demonstrate that the proposed model can achieve a reliable classification performance in a short term, yielding the mean accuracies of 0.687±0.005 and 0.650±0.014 in ASD and ADHD datasets, respectively. The graph-based feature selection method and MMoE model are demonstrated to make great contribution to performance improvement.

Research Area(s)

  • Autism spectrum disorder (ASD), attention deficit hyperactivity disorder (ADHD), multi-task learning (MTL), functional magnetic resonance imaging (fMRI), functional connectivity (FC)

Citation Format(s)

Multi-Task Learning for Efficient Diagnosis of ASD and ADHD using Resting-State fMRI data. / Huang, Zhi-An; Liu, Rui; Tan, Kay Chen.

2020. Paper presented at 2020 International Joint Conference on Neural Networks (IJCNN 2020), Glasgow, United Kingdom.

Research output: Conference Papers (RGC: 31A, 31B, 32, 33)32_Refereed conference paper (no ISBN/ISSN)