Multiplex single-nucleotide polymorphism typing by nanoparticle-coupled DNA-templated reactions
Research output: Journal Publications and Reviews › RGC 21 - Publication in refereed journal › peer-review
Author(s)
Detail(s)
Original language | English |
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Pages (from-to) | 11668-11669 |
Journal / Publication | Journal of the American Chemical Society |
Volume | 131 |
Issue number | 33 |
Publication status | Published - 26 Aug 2009 |
Externally published | Yes |
Link(s)
Abstract
(Figure Presented) A novel chip-based detection approach for single-nucleotide polymorphism (SNP) typing based on nanoparticle-coupled DNA-templated ligation reactions is reported. In contrast to conventional methods or recently developed techniques, this approach does not need costly instrumentation and complex stringency washing processes and offers both rapid multiplex SNP detection capability and ultrahigh sensitivity. The ability of the approach to quickly identify the precise location of the single-base mismatch may provide a time-efficient method for high-throughput multiplex SNP genotyping. © 2009 American Chemical Society.
Citation Format(s)
Multiplex single-nucleotide polymorphism typing by nanoparticle-coupled DNA-templated reactions. / Xue, Xuejia; Xu, Wei; Wang, Feng et al.
In: Journal of the American Chemical Society, Vol. 131, No. 33, 26.08.2009, p. 11668-11669.
In: Journal of the American Chemical Society, Vol. 131, No. 33, 26.08.2009, p. 11668-11669.
Research output: Journal Publications and Reviews › RGC 21 - Publication in refereed journal › peer-review