Multiple RONS-Loaded Plasma-Activated Ice Microneedle Patches for Transdermal Treatment of Psoriasis

Research output: Journal Publications and ReviewsRGC 21 - Publication in refereed journalpeer-review

2 Scopus Citations
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Author(s)

  • Tong Wu
  • Jishen Zhang
  • Xixi Jing
  • Zewei Wang
  • Zijin Wu
  • Hao Zhang
  • Dingxin Liu
  • Mingzhe Rong

Detail(s)

Original languageEnglish
Pages (from-to)46123-46132
Journal / PublicationACS Applied Materials & Interfaces
Volume16
Issue number35
Online published24 Aug 2024
Publication statusPublished - 4 Sept 2024

Abstract

Cold atmospheric plasma (CAP) is a fledgling therapeutic technique for psoriasis treatment with noninvasiveness, but clinical adoption has been stifled by the insufficient production and delivery of plasma-generated reactive oxygen and nitrogen species (RONS). Herein, patches of air-discharge plasma-activated ice microneedles (PA-IMNs) loaded with multiple RONS are designed for local transdermal delivery to treat psoriasis as an alternative to direct CAP irradiation treatment. By mixing two RONS generated by the air-discharge plasma in the NOx mode and O3 mode, abundant high-valence RONS are produced and incorporated into PA-IMNs via complex gas−gas and gas−liquid reactions. The PA-IMNs abrogate keratinocyte overproliferation by inducing reactive oxygen species (ROS)-mediated loss of the mitochondrial membrane potential and apoptosis of keratinocytes. The in vivo transdermal treatment confirms that PA-IMNs produce significant anti-inflammatory and therapeutic actions for imiquimod (IMQ)-induced psoriasis-like dermatitis in mice by inhibiting the release of associated inflammatory factors while showing no evident systemic toxicity. Therefore, PA-IMNs have a large potential in transdermal delivery platforms as they overcome the limitations of using CAP directly in the clinical treatment of psoriasis. © 2024 American Chemical Society.

Research Area(s)

  • cold atmospheric plasma, plasma-activated ice microneedles, psoriasis, reactive oxygen and nitrogen species, transdermal delivery

Citation Format(s)

Multiple RONS-Loaded Plasma-Activated Ice Microneedle Patches for Transdermal Treatment of Psoriasis. / Wu, Tong; Zhang, Jishen; Jing, Xixi et al.
In: ACS Applied Materials & Interfaces, Vol. 16, No. 35, 04.09.2024, p. 46123-46132.

Research output: Journal Publications and ReviewsRGC 21 - Publication in refereed journalpeer-review