MULTINUCLEAR ORGANOMETALLIC RUTHENIUM-ARENE COMPLEXES FOR CANCER THERAPY

Research output: Chapters, Conference Papers, Creative and Literary WorksRGC 12 - Chapter in an edited book (Author)peer-review

20 Scopus Citations
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Author(s)

Detail(s)

Original languageEnglish
Title of host publicationMetallo-Drugs
Subtitle of host publicationDevelopment and Action of Anticancer Agents
EditorsAstrid Sigel, Helmut Sigel, Eva Freisinger
PublisherWalter de Gruyter GmbH
Chapter6
Pages171-198
ISBN (electronic)9783110470734, 9783110469905
ISBN (print)9783110469844, 9783110470741
Publication statusPublished - 2018
Externally publishedYes

Publication series

NameMetal Ions in Life Sciences
Volume18
ISSN (Print)1559-0836
ISSN (electronic)1868-0402

Abstract

There has been much recent interest in the development of therapeutic transition metal-based complexes in part fueled by the clinical success of the platinum(II) anticancer drug, cisplatin. Yet known platinum drugs are limited by their high toxicity, severe side-effects, and incidences of drug resistance. Organometallic ruthenium-arene complexes have risen to prominence as a pharmacophore due to the success of other ruthenium drug candidates in clinical trials. In this chapter, we highlight higher order multinuclear ruthenium-arene complexes and their respective investigations as chemotherapeutic agents. We discuss their unique structural properties and the associated biochemical evaluation in the context of anticancer drug design. We also review the structural considerations for the design of these scaffolds and new therapeutic applications that are uncovered for this class of complexes.

Research Area(s)

  • Arene ligands, Cancer therapy, Heterometallic complexes, Multinuclear complexes, Ruthenium

Citation Format(s)

MULTINUCLEAR ORGANOMETALLIC RUTHENIUM-ARENE COMPLEXES FOR CANCER THERAPY. / Babak, Maria V.; Ang, Wee Han.
Metallo-Drugs: Development and Action of Anticancer Agents. ed. / Astrid Sigel; Helmut Sigel; Eva Freisinger. Walter de Gruyter GmbH, 2018. p. 171-198 (Metal Ions in Life Sciences; Vol. 18).

Research output: Chapters, Conference Papers, Creative and Literary WorksRGC 12 - Chapter in an edited book (Author)peer-review