Multimodal Visualization of Bioorthogonal Systems by Off–On Luminescence and Enhanced Magnetic Resonance Imaging

Chen Xie; Yue Wu; Ho-Fai Chau; Tao Zhang; Carlos Tinlong Wong; Yik-Hoi Yeung; Pak-Lun Lam; Jean-Claude G. Bünzli; Loïc J. Charbonnière; Ga-Lai Law; Ka-Leung Wong

doi:10.1002/adom.202203057

Multimodal Visualization of Bioorthogonal Systems by Off–On Luminescence and Enhanced Magnetic Resonance Imaging

Chen Xie
, Yue Wu
, Ho-Fai Chau
, Tao Zhang^*
, Carlos Tinlong Wong
, Yik-Hoi Yeung
, Pak-Lun Lam
, Jean-Claude G. Bünzli
, Loïc J. Charbonnière^*
, Ga-Lai Law^*
, Ka-Leung Wong^*

^*Corresponding author for this work

Research output: Journal Publications and Reviews › RGC 21 - Publication in refereed journal › peer-review

7 Citations (Scopus)

Abstract

Bioorthogonal chemistry is a rising field investigating chemical reactions in physiological environments with high specificity. However, only very few examples concern the real-time monitoring of bioorthogonal reactions by luminescence or magnetic relaxivity. To fill this gap, herein, the Eu(III)-based complex is reported as a small-molecule optical imaging agent which shows off–on luminescence and provides quantitative analysis for the progress of the bioorthogonal reaction. The characteristic signal is achieved through efficient energy harvesting and transferring to the Eu(III) from the expansion of the conjugated system of the antenna. Moreover, the gadolinium(III) counterpart significantly enhances relaxivity in magnetic resonance imaging (MRI) after the bioorthogonal reaction since the rotational correlation time is shortened with increased molecular sizes and weights. © 2023 The Authors. Advanced Optical Materials published by Wiley-VCH GmbH.

Original language	English
Article number	2203057
Journal	Advanced Optical Materials
Volume	11
Issue number	11
Online published	8 Mar 2023
DOIs	https://doi.org/10.1002/adom.202203057
Publication status	Published - 5 Jun 2023
Externally published	Yes

Funding

C.X. and Y.W. contributed equally to this work. G.-L.L. gratefully acknowledges The Hong Kong Polytechnic University ((a) University Research Facility in Chemical and Environmental Analysis (UCEA); (b) University Research Facility in Life Sciences (ULS)) and the Hong Kong Research (grant Nos. 15300919, 15301120, and 153021/18P). K.-L.W. gratefully acknowledges the financial assistance from the Hong Kong Research Grants Council (grant No. 12300021), Dr. Mok Man Hung Endowed Professorship in Chemistry, HKBU–Durham Lanthanide Joint Research Center – Lanthanide Tools for Systems Medicine (grant No. SDF19-1011-P02), and the Centre for Medical Engineering of Molecular and Biological Probes (grant No. AoE/M-401/20).

Research Keywords

bioorthogonal chemistry
lanthanides
luminescence
magnetic resonance imaging

Publisher's Copyright Statement

This full text is made available under CC-BY-NC 4.0. https://creativecommons.org/licenses/by-nc/4.0/

RGC Funding Information

RGC-funded

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title = "Multimodal Visualization of Bioorthogonal Systems by Off–On Luminescence and Enhanced Magnetic Resonance Imaging",

abstract = "Bioorthogonal chemistry is a rising field investigating chemical reactions in physiological environments with high specificity. However, only very few examples concern the real-time monitoring of bioorthogonal reactions by luminescence or magnetic relaxivity. To fill this gap, herein, the Eu(III)-based complex is reported as a small-molecule optical imaging agent which shows off–on luminescence and provides quantitative analysis for the progress of the bioorthogonal reaction. The characteristic signal is achieved through efficient energy harvesting and transferring to the Eu(III) from the expansion of the conjugated system of the antenna. Moreover, the gadolinium(III) counterpart significantly enhances relaxivity in magnetic resonance imaging (MRI) after the bioorthogonal reaction since the rotational correlation time is shortened with increased molecular sizes and weights. {\textcopyright} 2023 The Authors. Advanced Optical Materials published by Wiley-VCH GmbH.",

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author = "Chen Xie and Yue Wu and Ho-Fai Chau and Tao Zhang and Wong, \{Carlos Tinlong\} and Yik-Hoi Yeung and Pak-Lun Lam and B{\"u}nzli, \{Jean-Claude G.\} and Charbonni{\`e}re, \{Lo{\"i}c J.\} and Ga-Lai Law and Ka-Leung Wong",

year = "2023",

month = jun,

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doi = "10.1002/adom.202203057",

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T1 - Multimodal Visualization of Bioorthogonal Systems by Off–On Luminescence and Enhanced Magnetic Resonance Imaging

AU - Xie, Chen

AU - Wu, Yue

AU - Chau, Ho-Fai

AU - Zhang, Tao

AU - Wong, Carlos Tinlong

AU - Yeung, Yik-Hoi

AU - Lam, Pak-Lun

AU - Bünzli, Jean-Claude G.

AU - Charbonnière, Loïc J.

AU - Law, Ga-Lai

AU - Wong, Ka-Leung

PY - 2023/6/5

Y1 - 2023/6/5

N2 - Bioorthogonal chemistry is a rising field investigating chemical reactions in physiological environments with high specificity. However, only very few examples concern the real-time monitoring of bioorthogonal reactions by luminescence or magnetic relaxivity. To fill this gap, herein, the Eu(III)-based complex is reported as a small-molecule optical imaging agent which shows off–on luminescence and provides quantitative analysis for the progress of the bioorthogonal reaction. The characteristic signal is achieved through efficient energy harvesting and transferring to the Eu(III) from the expansion of the conjugated system of the antenna. Moreover, the gadolinium(III) counterpart significantly enhances relaxivity in magnetic resonance imaging (MRI) after the bioorthogonal reaction since the rotational correlation time is shortened with increased molecular sizes and weights. © 2023 The Authors. Advanced Optical Materials published by Wiley-VCH GmbH.

AB - Bioorthogonal chemistry is a rising field investigating chemical reactions in physiological environments with high specificity. However, only very few examples concern the real-time monitoring of bioorthogonal reactions by luminescence or magnetic relaxivity. To fill this gap, herein, the Eu(III)-based complex is reported as a small-molecule optical imaging agent which shows off–on luminescence and provides quantitative analysis for the progress of the bioorthogonal reaction. The characteristic signal is achieved through efficient energy harvesting and transferring to the Eu(III) from the expansion of the conjugated system of the antenna. Moreover, the gadolinium(III) counterpart significantly enhances relaxivity in magnetic resonance imaging (MRI) after the bioorthogonal reaction since the rotational correlation time is shortened with increased molecular sizes and weights. © 2023 The Authors. Advanced Optical Materials published by Wiley-VCH GmbH.

KW - bioorthogonal chemistry

KW - lanthanides

KW - luminescence

KW - magnetic resonance imaging

UR - https://www.scopus.com/pages/publications/85150510656

UR - https://www.scopus.com/pages/publications/85150510656#tab=impact

U2 - 10.1002/adom.202203057

DO - 10.1002/adom.202203057

M3 - RGC 21 - Publication in refereed journal

SN - 2195-1071

VL - 11

JO - Advanced Optical Materials

JF - Advanced Optical Materials

IS - 11

M1 - 2203057

ER -

Multimodal Visualization of Bioorthogonal Systems by Off–On Luminescence and Enhanced Magnetic Resonance Imaging

Abstract

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Research Keywords

Publisher's Copyright Statement

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