Multifunctional Tetracene/Pentacene Host/Guest Nanorods for Enhanced Upconversion Photodynamic Tumor Therapy

Research output: Journal Publications and Reviews (RGC: 21, 22, 62)21_Publication in refereed journalNot applicablepeer-review

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Author(s)

  • Yan Guan
  • Zhiyan Zhu
  • Hongying Lv
  • Futian Li
  • Shuqing Sun
  • Juan Li

Related Research Unit(s)

Detail(s)

Original languageEnglish
Pages (from-to)37479-37490
Journal / PublicationACS Applied Materials and Interfaces
Volume11
Issue number41
Online published18 Sep 2019
Publication statusPublished - 16 Oct 2019

Abstract

The tissue penetration depth of light and the singlet oxygen (1O2) generation efficiency of photosensitizers (PSs) are the two main factors that determine the effectiveness of photodynamic therapy for tumors. Herein, we report a novel strategy to prepare a multifunctional upconversion photosensitizer (UCPS) based on the host/guest nanoarchitecture. By a simple reprecipitation method, host/guest tetracene/pentacene nanorods (Tc/Pc NRs) were synthesized for enhancing triplet-triplet annihilation-upconversion (TTA-UC) or two-photon excited emission and 1O2 generation efficiency upon 650 or 808 nm excitation. Tc/Pc NRs had higher 1O2 quantum yield (74%) than Tc NRs (28%) upon 650 nm laser irradiation. The proposed mechanism is that doping Pc molecules into Tc NRs induces intermediate states between S0 and S1, shortening the energy gap for 1O2 generation and resulting in TTA-UC emission. Equally important, with 808 nm fs laser excitation, Tc/Pc NRs showed an enhanced 1O2 generation efficiency and two-photon absorption cross section (σ) compared with Tc NRs. In addition, when the tumors in mice were exposed to Tc/Pc NRs with 650 or 808 nm wavelength irradiation, the tumor inhibition rates achieved 99 and 95%, respectively. This work opens new perspectives for exploring novel nano-UCPSs for biomedical applications.

Research Area(s)

  • host/guest, photodynamic therapy, photosensitizers, singlet oxygen quantum yield, upconversion

Citation Format(s)

Multifunctional Tetracene/Pentacene Host/Guest Nanorods for Enhanced Upconversion Photodynamic Tumor Therapy. / Zhang, Rui; Guan, Yan; Zhu, Zhiyan; Lv, Hongying; Li, Futian; Sun, Shuqing; Li, Juan.

In: ACS Applied Materials and Interfaces, Vol. 11, No. 41, 16.10.2019, p. 37479-37490.

Research output: Journal Publications and Reviews (RGC: 21, 22, 62)21_Publication in refereed journalNot applicablepeer-review