Multifunctional Nanoprobe for the Delivery of Therapeutic siRNA and Real-Time Molecular Imaging of Parkinson's Disease Biomarkers

Research output: Journal Publications and ReviewsRGC 21 - Publication in refereed journalpeer-review

15 Scopus Citations
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Author(s)

  • Rui Li
  • Yi Li
  • Mingdao Mu
  • Boguang Yang
  • Xiaoyu Chen
  • Wayne Yuk Wai Lee
  • Ya Ke
  • Ben Zhong Tang
  • Liming Bian

Detail(s)

Original languageEnglish
Pages (from-to)11609-11620
Journal / PublicationACS Applied Materials and Interfaces
Volume13
Issue number10
Online published8 Mar 2021
Publication statusPublished - 17 Mar 2021
Externally publishedYes

Abstract

Parkinson's disease (PD) has been recently associated with the excessive expression of matrix metalloproteinase 3 (MMP3). One of the major challenges in treating PD is to effectively detect and inhibit the early MMP3 activities to relieve the neural stress and inflammation responses. Previously, numerous upconversion nanoparticle (UCNP)-based nanoprobes have been designed for the detection of biomarkers in neurodegenerative diseases. To further improve the performance of the conventional nanoprobes, we introduced novel reporting units and integrated the therapeutic reagents to fabricate a theragnostic platform for PD and other neurodegenerative diseases. Here, we designed a multifunctional UCNP/aggregation-induced emission luminogen (AIEgen)-based nanoprobe to effectively detect the time-lapse MMP3 activities in the inflammatory catecholaminergic SH-SY5Y cells and simultaneously deliver the MMP3-siRNA into the stressed catecholaminergic SH-SY5Y cells, inhibiting the MMP3-induced inflammatory neural responses. The unique features of our UCNP/AIEgen-based nanoprobe platform shed light on the development of a novel theragnostic probe for the early diagnosis and cure of neurodegenerative diseases. © 2021 American Chemical Society.

Research Area(s)

  • aggregation-induced emission, biomarker-triggered nanoprobe, metalloproteinase 3, Parkinson's disease, upconversion nanoparticles

Citation Format(s)

Multifunctional Nanoprobe for the Delivery of Therapeutic siRNA and Real-Time Molecular Imaging of Parkinson's Disease Biomarkers. / Li, Rui; Li, Yi; Mu, Mingdao et al.
In: ACS Applied Materials and Interfaces, Vol. 13, No. 10, 17.03.2021, p. 11609-11620.

Research output: Journal Publications and ReviewsRGC 21 - Publication in refereed journalpeer-review