Multifunctional nanoparticles for upconversion luminescence/MR multimodal imaging and magnetically targeted photothermal therapy

Research output: Journal Publications and Reviews (RGC: 21, 22, 62)21_Publication in refereed journal

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Author(s)

  • Liang Cheng
  • Kai Yang
  • Yonggang Li
  • Xiao Zeng
  • Mingwang Shao
  • And 2 others
  • Shuit-Tong Lee
  • Zhuang Liu

Detail(s)

Original languageEnglish
Pages (from-to)2215-2222
Journal / PublicationBiomaterials
Volume33
Issue number7
Publication statusPublished - Mar 2012

Abstract

Theranostics, the combination of diagnostics and therapies, has become a new concept in the battles with various major diseases such as cancer. Herein, we develop multifunctional nanoparticles (MFNPs) with highly integrated functionalities including upconversion luminescence, superparamagnetism, and strong optical absorption in the near-infrared (NIR) region with high photostability. Invivo dual modal optical/magnetic resonance imaging of mice uncovers that by placing a magnet nearby the tumor, MFNPs tend to migrate toward the tumor after intravenous injection and show high tumor accumulation, which is ∼8 folds higher than that without magnetic targeting. NIR laser irradiation is then applied to the tumors grown on MFNP-injected mice under magnetic tumor-targeting, obtaining an outstanding photothermal therapeutic efficacy with 100% of tumor elimination in a murine breast cancer model. We present here a strategy for multimodal imaging-guided, magnetically targeted physical cancer therapy and highlight the promise of using multifunctional nanostructures for cancer theranostics. © 2011 Elsevier Ltd.

Research Area(s)

  • Invivo cancer treatment, Magnetic tumor targeting, Multifunctional nanoparticles, Multimodal imaging, Photothermal therapy

Citation Format(s)

Multifunctional nanoparticles for upconversion luminescence/MR multimodal imaging and magnetically targeted photothermal therapy. / Cheng, Liang; Yang, Kai; Li, Yonggang; Zeng, Xiao; Shao, Mingwang; Lee, Shuit-Tong; Liu, Zhuang.

In: Biomaterials, Vol. 33, No. 7, 03.2012, p. 2215-2222.

Research output: Journal Publications and Reviews (RGC: 21, 22, 62)21_Publication in refereed journal