Multifunctional hydrogel electronics for closed-loop antiepileptic treatment
Research output: Journal Publications and Reviews › RGC 21 - Publication in refereed journal › peer-review
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Original language | English |
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Article number | eadq9207 |
Journal / Publication | Science Advances |
Volume | 10 |
Issue number | 47 |
Publication status | Published - 22 Nov 2024 |
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DOI | DOI |
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Link to Scopus | https://www.scopus.com/record/display.uri?eid=2-s2.0-85210127725&origin=recordpage |
Permanent Link | https://scholars.cityu.edu.hk/en/publications/publication(2d27820d-b60e-46fb-83dd-0a456934368b).html |
Abstract
Closed-loop strategies offer advanced therapeutic potential through intelligent disease management. Here, we develop a hydrogel-based, single-component, organic electronic device for closed-loop neurotherapy. Fabricated out of conductive hydrogels, the device consists of a flexible array of microneedle electrodes, each of which can be individually addressed to perform electrical recording and control chemical release with sophisticated spatiotemporal control, thus pioneering a smart antiseizure therapeutic system by combining electrical and pharmacological interventions. The recorded neural signal acts as the trigger for a voltage-driven drug release in detected pathological conditions predicted by real-time electrophysiology analysis. When implanted into epileptic animals, the device enables autonomous antiseizure management, where the dosing of antiepileptic drug is controlled in a time-sensitive, region-selective, and dose-adaptive manner, allowing the inhibition of seizure outbursts through the delivery of just-necessary drug dosages. The side effects are minimized with dosages three orders of magnitude lower than the usage in approaches simulating existing clinical treatments. © 2024 American Association for the Advancement of Science. All rights reserved.
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Citation Format(s)
Multifunctional hydrogel electronics for closed-loop antiepileptic treatment. / Qu, Jin; Xie, Kai; Chen, Shu et al.
In: Science Advances, Vol. 10, No. 47, eadq9207, 22.11.2024.
In: Science Advances, Vol. 10, No. 47, eadq9207, 22.11.2024.
Research output: Journal Publications and Reviews › RGC 21 - Publication in refereed journal › peer-review
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