Multifunctional chondroitin sulphate for cartilage tissue-biomaterial integration

Dong-An Wang; Shyni Varghese; Blanka Sharma; Iossif Strehin; Sara Fermanian; Justin Gorham; D. Howard Fairbrother; Brett Cascio; Jennifer H. Elisseeff

doi:10.1038/nmat1890

Multifunctional chondroitin sulphate for cartilage tissue-biomaterial integration

Dong-An Wang, Shyni Varghese, Blanka Sharma, Iossif Strehin, Sara Fermanian, Justin Gorham, D. Howard Fairbrother, Brett Cascio, Jennifer H. Elisseeff^*

^*Corresponding author for this work

Research output: Journal Publications and Reviews › RGC 21 - Publication in refereed journal › peer-review

646 Citations (Scopus)

Abstract

A biologically active, high-strength tissue adhesive is needed for numerous medical applications in tissue engineering and regenerative medicine. Integration of biomaterials or implants with surrounding native tissue is crucial for both immediate functionality and long-term performance of the tissue. Here, we use the biopolymer chondroitin sulphate (CS), one of the major components of cartilage extracellular matrix, to develop a novel bioadhesive that is readily applied and acts quickly. CS was chemically functionalized with methacrylate and aldehyde groups on the polysaccharide backbone to chemically bridge biomaterials and tissue proteins via a twofold covalent link. Three-dimensional hydrogels (with and without cells) bonded to articular cartilage defects. In in vitro and in vivo functional studies this approach led to mechanical stability of the hydrogel and tissue repair in cartilage defects. © 2007 Nature Publishing Group.

Original language	English
Pages (from-to)	385-392
Journal	Nature Materials
Volume	6
Issue number	5
DOIs	https://doi.org/10.1038/nmat1890
Publication status	Published - May 2007
Externally published	Yes

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Publication details (e.g. title, author(s), publication statuses and dates) are captured on an “AS IS” and “AS AVAILABLE” basis at the time of record harvesting from the data source. Suggestions for further amendments or supplementary information can be sent to [email protected].

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title = "Multifunctional chondroitin sulphate for cartilage tissue-biomaterial integration",

abstract = "A biologically active, high-strength tissue adhesive is needed for numerous medical applications in tissue engineering and regenerative medicine. Integration of biomaterials or implants with surrounding native tissue is crucial for both immediate functionality and long-term performance of the tissue. Here, we use the biopolymer chondroitin sulphate (CS), one of the major components of cartilage extracellular matrix, to develop a novel bioadhesive that is readily applied and acts quickly. CS was chemically functionalized with methacrylate and aldehyde groups on the polysaccharide backbone to chemically bridge biomaterials and tissue proteins via a twofold covalent link. Three-dimensional hydrogels (with and without cells) bonded to articular cartilage defects. In in vitro and in vivo functional studies this approach led to mechanical stability of the hydrogel and tissue repair in cartilage defects. {\textcopyright} 2007 Nature Publishing Group.",

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T1 - Multifunctional chondroitin sulphate for cartilage tissue-biomaterial integration

AU - Wang, Dong-An

AU - Varghese, Shyni

AU - Sharma, Blanka

AU - Strehin, Iossif

AU - Fermanian, Sara

AU - Gorham, Justin

AU - Fairbrother, D. Howard

AU - Cascio, Brett

AU - Elisseeff, Jennifer H.

N1 - Publication details (e.g. title, author(s), publication statuses and dates) are captured on an “AS IS” and “AS AVAILABLE” basis at the time of record harvesting from the data source. Suggestions for further amendments or supplementary information can be sent to [email protected].

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N2 - A biologically active, high-strength tissue adhesive is needed for numerous medical applications in tissue engineering and regenerative medicine. Integration of biomaterials or implants with surrounding native tissue is crucial for both immediate functionality and long-term performance of the tissue. Here, we use the biopolymer chondroitin sulphate (CS), one of the major components of cartilage extracellular matrix, to develop a novel bioadhesive that is readily applied and acts quickly. CS was chemically functionalized with methacrylate and aldehyde groups on the polysaccharide backbone to chemically bridge biomaterials and tissue proteins via a twofold covalent link. Three-dimensional hydrogels (with and without cells) bonded to articular cartilage defects. In in vitro and in vivo functional studies this approach led to mechanical stability of the hydrogel and tissue repair in cartilage defects. © 2007 Nature Publishing Group.

AB - A biologically active, high-strength tissue adhesive is needed for numerous medical applications in tissue engineering and regenerative medicine. Integration of biomaterials or implants with surrounding native tissue is crucial for both immediate functionality and long-term performance of the tissue. Here, we use the biopolymer chondroitin sulphate (CS), one of the major components of cartilage extracellular matrix, to develop a novel bioadhesive that is readily applied and acts quickly. CS was chemically functionalized with methacrylate and aldehyde groups on the polysaccharide backbone to chemically bridge biomaterials and tissue proteins via a twofold covalent link. Three-dimensional hydrogels (with and without cells) bonded to articular cartilage defects. In in vitro and in vivo functional studies this approach led to mechanical stability of the hydrogel and tissue repair in cartilage defects. © 2007 Nature Publishing Group.

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DO - 10.1038/nmat1890

M3 - RGC 21 - Publication in refereed journal

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SN - 1476-1122

VL - 6

SP - 385

EP - 392

JO - Nature Materials

JF - Nature Materials

IS - 5

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Multifunctional chondroitin sulphate for cartilage tissue-biomaterial integration

Abstract

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