TY - JOUR
T1 - Multicolor in vivo imaging of upconversion nanoparticles with emissions tuned by luminescence resonance energy transfer
AU - Cheng, Liang
AU - Yang, Kai
AU - Shao, Mingwang
AU - Lee, Shuit-Tong
AU - Liu, Zhuang
PY - 2011/2/17
Y1 - 2011/2/17
N2 - Upconversion nanoparticles (UCNPs) based on sodium yttrium fluoride (NaYF4) nanocrystals are synthesized, functionalized with an amphiphilic polymer, and loaded with fluorescent and quenching molecules by physical adsorption. The formed supramolecular UCNP-dye complexes show tuned visible emission spectra owing to the luminescence resonance energy transfer (LRET) from nanoparticles to the organic dyes under near-infrared (NIR) excitation, and can be well separated in multicolor imaging after spectral decovolution. Our work provides a facile and flexible method to modulate the upconversion luminescence (UCL) spectra of UCNPs for in vivo multicolor UCL imaging in animals. © 2011 American Chemical Society.
AB - Upconversion nanoparticles (UCNPs) based on sodium yttrium fluoride (NaYF4) nanocrystals are synthesized, functionalized with an amphiphilic polymer, and loaded with fluorescent and quenching molecules by physical adsorption. The formed supramolecular UCNP-dye complexes show tuned visible emission spectra owing to the luminescence resonance energy transfer (LRET) from nanoparticles to the organic dyes under near-infrared (NIR) excitation, and can be well separated in multicolor imaging after spectral decovolution. Our work provides a facile and flexible method to modulate the upconversion luminescence (UCL) spectra of UCNPs for in vivo multicolor UCL imaging in animals. © 2011 American Chemical Society.
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U2 - 10.1021/jp111006z
DO - 10.1021/jp111006z
M3 - RGC 21 - Publication in refereed journal
SN - 1932-7447
VL - 115
SP - 2686
EP - 2692
JO - The Journal of Physical Chemistry C
JF - The Journal of Physical Chemistry C
IS - 6
ER -