Monocarboxylate transporter 1 in Schwann cells contributes to maintenance of sensory nerve myelination during aging

Research output: Journal Publications and Reviews (RGC: 21, 22, 62)21_Publication in refereed journal

6 Scopus Citations
View graph of relations

Author(s)

  • Mithilesh Kumar Jha
  • Katelyn A. Russell
  • Fang Yang
  • Raha M. Dastgheyb
  • Pragney Deme
  • Xanthe H. Ament
  • Weiran Chen
  • Ying Liu
  • Yun Guan
  • Michael J. Polydefkis
  • Ahmet Hoke
  • Norman J. Haughey
  • Jeffrey D. Rothstein
  • Brett M. Morrison

Related Research Unit(s)

Detail(s)

Original languageEnglish
Pages (from-to)161-177
Journal / PublicationGLIA
Volume68
Issue number1
Online published27 Aug 2019
Publication statusPublished - Jan 2020

Abstract

Schwann cell (SC)-specific monocarboxylate transporter 1 (MCT1) knockout mice were generated by mating MCT1f/f mice with myelin protein zero (P0)-Cre mice. P0-Cre+/−, MCT1f/f mice have no detectable early developmental defects, but develop hypomyelination and reduced conduction velocity in sensory, but not motor, peripheral nerves during maturation and aging. Furthermore, reduced mechanical sensitivity is evident in aged P0-Cre+/−, MCT1f/f mice. MCT1 deletion in SCs impairs both their glycolytic and mitochondrial functions, leading to altered lipid metabolism of triacylglycerides, diacylglycerides, and sphingomyelin, decreased expression of myelin-associated glycoprotein, and increased expression of c-Jun and p75-neurotrophin receptor, suggesting a regression of SCs to a less mature developmental state. Taken together, our results define the contribution of SC MCT1 to both SC metabolism and peripheral nerve maturation and aging.

Research Area(s)

  • lactate, MCT1, metabolism, monocarboxylate transporter, myelination, peripheral nerve, Schwann cell, sensory axons, triacylglycerides

Citation Format(s)

Monocarboxylate transporter 1 in Schwann cells contributes to maintenance of sensory nerve myelination during aging. / Jha, Mithilesh Kumar; Lee, Youngjin; Russell, Katelyn A.; Yang, Fang; Dastgheyb, Raha M.; Deme, Pragney; Ament, Xanthe H.; Chen, Weiran; Liu, Ying; Guan, Yun; Polydefkis, Michael J.; Hoke, Ahmet; Haughey, Norman J.; Rothstein, Jeffrey D.; Morrison, Brett M.

In: GLIA, Vol. 68, No. 1, 01.2020, p. 161-177.

Research output: Journal Publications and Reviews (RGC: 21, 22, 62)21_Publication in refereed journal