Projects per year
Abstract
Motivation: Theranostic application of intranasal drug delivery to glioblastoma using multiple CEST contrast.
Goal(s): Our goal is to monitor the drug delivery to brain tumor and evaluate the treatment effect simultaneously.
Approach: We investigated the imaging of liposome-based drug delivery to the brain tumor via intranasal administration,in which the amount of liposome and the tumor response can be detected by CEST MRI at 3T.
Results: CEST contrast at 3.5ppm of tumor region and the tumor size comparison between treatment and control group could indicate the therapeutic effect.CEST contrast at 4.3and-3.5ppm from pre-injection to post-injection in-vivo,could indicate the liposome drug delivery efficacy and drug distribution.
Impact: CEST MRI guided intranasal drug delivery could provide valuable information for assessing efficacy of drug delivery and treatment outcome. This can potentially translate to clinics as a non-invasive theranostic approach for glioblastoma treatment.
Goal(s): Our goal is to monitor the drug delivery to brain tumor and evaluate the treatment effect simultaneously.
Approach: We investigated the imaging of liposome-based drug delivery to the brain tumor via intranasal administration,in which the amount of liposome and the tumor response can be detected by CEST MRI at 3T.
Results: CEST contrast at 3.5ppm of tumor region and the tumor size comparison between treatment and control group could indicate the therapeutic effect.CEST contrast at 4.3and-3.5ppm from pre-injection to post-injection in-vivo,could indicate the liposome drug delivery efficacy and drug distribution.
Impact: CEST MRI guided intranasal drug delivery could provide valuable information for assessing efficacy of drug delivery and treatment outcome. This can potentially translate to clinics as a non-invasive theranostic approach for glioblastoma treatment.
| Original language | English |
|---|---|
| Publication status | Published - May 2024 |
| Event | 2024 ISMRM & ISMRT Annual Meeting & Exhibition - Suntec Singapore Convention & Exhibition Centre, Singapore Duration: 4 May 2024 → 9 May 2024 https://www.ismrm.org/24m/ |
Conference
| Conference | 2024 ISMRM & ISMRT Annual Meeting & Exhibition |
|---|---|
| Place | Singapore |
| Period | 4/05/24 → 9/05/24 |
| Internet address |
Bibliographical note
Author(s) information for this publication is provided by the author(s) concerned.Funding
This work was supported by Research Grants Council (11102218, 11200422, RFS2223-1S02, C1134-20G), City University of Hong Kong (7005433, 7005626, 9609307, 9610560 and 9610616), National Natural Science Foundation of China (81871409), Tung Biomedical Sciences Centre and Hong Kong Centre for Cerebro-cardiovascular Health Engineering.
Research Keywords
- Tumors (Post-Treatment)
- CEST & MT
- Glioblastoma
- Intranasal
- Theranostic
Fingerprint
Dive into the research topics of 'Monitoring intranasal treatment to brain tumor using multiple CEST contrasts'. Together they form a unique fingerprint.-
GRF: Imaging Nose-to-brain Drug Delivery to Brain Tumors Using Multiple CEST MRI Contrast
CHAN, W. Y. K. (Principal Investigator / Project Coordinator) & LEUNG, G. K. K. (Co-Investigator)
1/01/23 → …
Project: Research
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RFS: Non-invasive CEST MRI Detects Reduced CSF Clearance in the Brain for Early Diagnosis of Alzheimer’s Disease
CHAN, W. Y. K. (Principal Investigator / Project Coordinator)
1/01/23 → …
Project: Research
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CRF: A Novel Vaccination Strategy: Using a Microrobot Platform for DNA Vaccine Delivery and Antigen Presentation
FENG, G. G. (Principal Investigator / Project Coordinator), CHAN, W. Y. K. (Co-Principal Investigator), Chen, Z. (Co-Principal Investigator), MAN, N. K. (Co-Principal Investigator), Tan, Z. (Co-Principal Investigator) & ZHANG, L. (Co-Principal Investigator)
1/06/21 → …
Project: Research
Prizes
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ISMRM2024 Magna Cum Laude Merit Award
LAW, L. H. (Recipient) & CHAN, W. Y. K. (Recipient), May 2024
Prize: RGC 64B - Prizes and awards
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Activities
- 1 Conference / Symposium
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2024 ISMRM & ISMRT Annual Meeting & Exhibition
SU, H. (Participant)
4 May 2024 → 9 May 2024Activity: Organizing or Participating in a conference / an event › Conference / Symposium