Molecular staging of marine medaka : A model organism for marine ecotoxicity study

Research output: Journal Publications and Reviews (RGC: 21, 22, 62)21_Publication in refereed journalpeer-review

33 Scopus Citations
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Author(s)

  • Xueping Chen
  • Li Li
  • Jinping Cheng
  • Da-Zhi Wang
  • Ke-Jian Wang
  • Michael E. Baker
  • Gary Hardiman
  • Daniel Schlenk

Detail(s)

Original languageEnglish
Pages (from-to)309-317
Journal / PublicationMarine Pollution Bulletin
Volume63
Issue number5-12
Publication statusPublished - 2011

Abstract

Oryzias melastigma, also called O. dancena, is becoming a very useful model for estuarine and marine ecotoxicity studies. With O. melastigma being adopted by ILSI Health and Environmental Science Institute (HESI) for embryo toxicity testing, improved knowledge of biomarker based embryonic development becomes especially important for mechanism-based toxicity evaluations. Using whole mount in situ hybridization and immunostaining techniques together with widely used molecular markers, this study describes the molecular development of marine medaka embryos, focusing on the brain, eye, heart, pectoral fin, pancreas, liver, muscle and neuron system. These organs are targets of environmental pollutants that disrupt normal embryonic development in medaka and other fish. © 2011 Elsevier Ltd.

Research Area(s)

  • Immunostaining, In situ hybridization, Medaka, Molecular staging, Oryzias melastigma

Citation Format(s)

Molecular staging of marine medaka : A model organism for marine ecotoxicity study. / Chen, Xueping; Li, Li; Cheng, Jinping; Chan, Leo Lai; Wang, Da-Zhi; Wang, Ke-Jian; Baker, Michael E.; Hardiman, Gary; Schlenk, Daniel; Cheng, Shuk Han.

In: Marine Pollution Bulletin, Vol. 63, No. 5-12, 2011, p. 309-317.

Research output: Journal Publications and Reviews (RGC: 21, 22, 62)21_Publication in refereed journalpeer-review