Molecular Recognition in Anion Coordination Chemistry. Structure, Binding Constants and Receptor‐Substrate Complementarity of a Series of Anion Cryptates of a Macrobicyclic Receptor Molecule

Research output: Journal Publications and Reviews (RGC: 21, 22, 62)21_Publication in refereed journalpeer-review

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Detail(s)

Original languageEnglish
Pages (from-to)91-104
Journal / PublicationHelvetica Chimica Acta
Volume67
Issue number1
Publication statusPublished - 1 Feb 1984
Externally publishedYes

Abstract

The crystal structures of four anion cryptates [X<sup>−</sup> ⊂ BT‐6H<sup>+</sup>] formed by the protonated macrobicyclic receptor BT‐6H<sup>+</sup> with F<sup>−</sup>, Cl<sup>−</sup>, Br<sup>−</sup> and N 3− have been determined. They provide a homogeneous series of anion coordination patterns with the same ligand. The small F<sup>−</sup>‐ion is tetracoordinated, while Cl<sup>−</sup> and Br<sup>−</sup> are bound in an octahedron of H‐bonds. The non‐complementarity between these spherical anions and the ellipsoïdal cavity of BT‐6H<sup>+</sup> is reflected in ligand distortions. Structural complementarity is achieved for the linear triatomic substrate N 3−, which is bound by two pyramidal arrays of three H‐bonds, each interacting with a terminal N‐atom of N 3−. The formation constants of the complexes formed by BT‐6H<sup>+</sup> with a variety of anions (halides, N 3−, NO 3−, carboxylates, SO 42−, HPO 42−, AMP<sup>2−</sup>, ADP<sup>3−</sup>, ATP<sup>4−</sup>, P<sub>2</sub>O 74−) have been determined. Very strong complexations are found, as well as marked electrostatic and structural effects on stability and selectivity; in particular the binding of F<sup>−</sup>, Cl<sup>−</sup>, Br<sup>−</sup>, and N 3− may be analyzed in terms of the crystal structure data. The cryptand BT‐6H<sup>+</sup> is a molecular receptor containing an ellipsoïdal recognition site for linear triatomic substrates of size compatible with the size of the molecular cacity. Further developments of various aspects of anion coordination chemistry are considered. Copyright © 1984 Verlag GmbH & Co. KGaA, Weinheim

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Citation Format(s)

Molecular Recognition in Anion Coordination Chemistry. Structure, Binding Constants and Receptor‐Substrate Complementarity of a Series of Anion Cryptates of a Macrobicyclic Receptor Molecule. / Dietrich, Bernard; Guilhem, Jean; Lehn, Jean‐Marie; Pascard, Claudine; Sonveaux, Etienne.

In: Helvetica Chimica Acta, Vol. 67, No. 1, 01.02.1984, p. 91-104.

Research output: Journal Publications and Reviews (RGC: 21, 22, 62)21_Publication in refereed journalpeer-review