Molecular Programming of NIR-IIb-Emissive Semiconducting Small Molecules for In Vivo High-Contrast Bioimaging Beyond 1500 nm

Research output: Journal Publications and Reviews (RGC: 21, 22, 62)21_Publication in refereed journalpeer-review

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Author(s)

  • Yi Yuan
  • Zhe Feng
  • Shengliang Li
  • Zhongming Huang
  • Yingpeng Wan
  • Sien Lin
  • Lan Wu
  • Jing Zhou
  • Liang-Sheng Liao
  • Jun Qian

Detail(s)

Original languageEnglish
Article number2201263
Journal / PublicationAdvanced Materials
Volume34
Issue number19
Online published8 Apr 2022
Publication statusPublished - 12 May 2022

Abstract

Materials with long-wavelength second near-infrared (NIR-II) emission are highly desired for in vivo dynamic visualizating of microstructures in deep tissues. Herein, by employing an atom-programming strategy, a series of highly fluorescent semiconducting oligomers (SOMs) with tunable NIR-IIb emissions are developed for bioimaging applications. After self-assembly into nanoparticles (NPs), they show good brightness, high photostability, and satisfactory biocompatibility. The SOM NPs are applied as probes for high-resolution imaging of whole-body and hind-limb blood vessels, biliary tract, and bladder with their emissions over 1500 nm. This work demonstrates an atom-programming strategy for constructing semiconducting small molecules with enhanced NIR-II fluorescence for deep-tissue imaging, affording new insight for advancing molecular design of NIR-II fluorophores.

Research Area(s)

  • fluorescence imaging, molecular programming, nanoparticles, NIR-II, semiconducting oligomers

Citation Format(s)

Molecular Programming of NIR-IIb-Emissive Semiconducting Small Molecules for In Vivo High-Contrast Bioimaging Beyond 1500 nm. / Yuan, Yi; Feng, Zhe; Li, Shengliang et al.

In: Advanced Materials, Vol. 34, No. 19, 2201263, 12.05.2022.

Research output: Journal Publications and Reviews (RGC: 21, 22, 62)21_Publication in refereed journalpeer-review