Molecular Programming of NIR-IIb-Emissive Semiconducting Small Molecules for In Vivo High-Contrast Bioimaging Beyond 1500 nm

Research output: Journal Publications and Reviews › RGC 21 - Publication in refereed journal › peer-review

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Author(s)

  • Yi Yuan (Co-first Author)
  • Zhe Feng (Co-first Author)
  • Shengliang Li
  • Zhongming Huang
  • Yingpeng Wan
  • Sien Lin
  • Lan Wu
  • Jing Zhou
  • Liang-Sheng Liao
  • Jun Qian

Related Research Unit(s)

Detail(s)

Original languageEnglish
Article number2201263
Journal / PublicationAdvanced Materials
Volume34
Issue number19
Online published8 Apr 2022
Publication statusPublished - 12 May 2022

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DOI

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Publisher's Copyright Statement
  • COPYRIGHT TERMS OF DEPOSITED POSTPRINT FILE: This is the accepted version of the following article: Yuan, Y., Feng, Z., Li, S., Huang, Z., Wan, Y., Cao, C., Lin, S., Wu, L., Zhou, J., Liao, L.-S., Qian, J., & Lee, C.-S. (2022). Molecular Programming of NIR-IIb-Emissive Semiconducting Small Molecules for In Vivo High-Contrast Bioimaging Beyond 1500 nm. Advanced Materials, 34(19), Article 2201263, which has been published in final form at https://doi.org/10.1002/adma.202201263. This article may be used for non-commercial purposes in accordance with Wiley Terms and Conditions for Use of Self-Archived Versions. This article may not be enhanced, enriched or otherwise transformed into a derivative work, without express permission from Wiley or by statutory rights under applicable legislation. Copyright notices must not be removed, obscured or modified. The article must be linked to Wiley’s version of record on Wiley Online Library and any embedding, framing or otherwise making available the article or pages thereof by third parties from platforms, services and websites other than Wiley Online Library must be prohibited.
Link to Scopus https://www.scopus.com/record/display.uri?eid=2-s2.0-85127630515&origin=recordpage
Permanent Link https://scholars.cityu.edu.hk/en/publications/publication(f2821d13-af76-4be4-ab0b-02da30e67e5a).html

Abstract

Materials with long-wavelength second near-infrared (NIR-II) emission are highly desired for in vivo dynamic visualizating of microstructures in deep tissues. Herein, by employing an atom-programming strategy, a series of highly fluorescent semiconducting oligomers (SOMs) with tunable NIR-IIb emissions are developed for bioimaging applications. After self-assembly into nanoparticles (NPs), they show good brightness, high photostability, and satisfactory biocompatibility. The SOM NPs are applied as probes for high-resolution imaging of whole-body and hind-limb blood vessels, biliary tract, and bladder with their emissions over 1500 nm. This work demonstrates an atom-programming strategy for constructing semiconducting small molecules with enhanced NIR-II fluorescence for deep-tissue imaging, affording new insight for advancing molecular design of NIR-II fluorophores.

Research Area(s)

  • fluorescence imaging, molecular programming, nanoparticles, NIR-II, semiconducting oligomers

Fingerprint

Publication fingerprints text

100
Nanoparticle Physics
100
Bioimaging Physics
100
Oligomer Physics
50
High Resolution Physics
50
Near Infrared Physics
50
Biocompatibility Physics
50
Self Assembly Physics
50
Molecular Design Chemistry
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Citation Format(s)

[ RIS ] [ BibTeX ]
Molecular Programming of NIR-IIb-Emissive Semiconducting Small Molecules for In Vivo High-Contrast Bioimaging Beyond 1500 nm. / Yuan, Yi (Co-first Author); Feng, Zhe (Co-first Author); Li, Shengliang et al.
In: Advanced Materials, Vol. 34, No. 19, 2201263, 12.05.2022.

Research output: Journal Publications and Reviews › RGC 21 - Publication in refereed journal › peer-review

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