Molecular Profile of Canine Hemangiosarcoma and Potential Novel Therapeutic Targets

Research output: Journal Publications and ReviewsRGC 21 - Publication in refereed journalpeer-review

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Author(s)

Detail(s)

Original languageEnglish
Article number387
Journal / PublicationVeterinary Sciences
Volume10
Issue number6
Online published5 Jun 2023
Publication statusPublished - Jun 2023

Link(s)

Abstract

Canine hemangiosarcoma (HSA) is a relatively common neoplasia, occurring mainly in the skin, spleen, liver and right atrium. Despite the numerous studies investigating the treatment of canine HSA, no significant improvement in survival has been achieved in the last 20 years. Advancements in genetic and molecular profiling presented molecular similarities between canine HSA and human angiosarcoma. It could therefore serve as a valuable model for investigating new and more effective treatments in people and dogs. The most common genetic abnormalities in canine HSA have been found in the phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha (PIK3CA) and neuroblastoma RAS viral oncogene homolog (NRAS) pathways. Mutations are also found in tumor protein p53 (TP53), phosphatase and tensin homolog (PTEN) and cyclin dependent kinase inhibitor 2A (CDKN2A). Known abnormal protein expression could be exploited to trial new target treatments that could be beneficial for both canine and human patients. Despite the high expression of vascular endothelial growth factor (VEGF) and its receptor (VEGFR), no correlation with overall survival time has ever been found. In this review, we explore the most recent developments in molecular profiling in canine HSA and discuss their possible applications in the prognosis and treatment of this fatal disease. © 2023 by the authors.

Research Area(s)

  • angiosarcoma, dog, NRAS, PIK3CA, VEGF, CDKN2A, PTEN, TP53

Citation Format(s)

Molecular Profile of Canine Hemangiosarcoma and Potential Novel Therapeutic Targets. / Pimentel, Pedro Antônio Bronhara; Giuliano, Antonio; Bęczkowski, Pawel Marek et al.
In: Veterinary Sciences, Vol. 10, No. 6, 387, 06.2023.

Research output: Journal Publications and ReviewsRGC 21 - Publication in refereed journalpeer-review

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