Molecular mechanisms underlying the high mortality of hypervirulent Klebsiella pneumoniae and its effective therapy development

Qi Xu; Miaomiao Xie; Xiaoxuan Liu; Heng Heng; Han Wang; Chen Yang; Edward Wai-Chi Chan; Rong Zhang; Guan Yang; Sheng Chen

doi:10.1038/s41392-023-01490-9

Molecular mechanisms underlying the high mortality of hypervirulent Klebsiella pneumoniae and its effective therapy development

Qi Xu
, Miaomiao Xie
, Xiaoxuan Liu
, Heng Heng
, Han Wang
, Chen Yang
, Edward Wai-Chi Chan
, Rong Zhang
, Guan Yang^*
, Sheng Chen^*

^*Corresponding author for this work

Research output: Journal Publications and Reviews › Letter › peer-review

25 Citations (Scopus)

88 Downloads (CityUHK Scholars)

Original language	English
Article number	221
Journal	Signal Transduction and Targeted Therapy
Volume	8
Online published	30 May 2023
DOIs	https://doi.org/10.1038/s41392-023-01490-9
Publication status	Published - 2023

Funding

This study was funded by the Theme-Based Research Scheme (T11-104/22-R) and the Research Impact Fund (R5011-18F) from the Research Grant Council of the Government of Hong Kong SAR.

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being

Research Keywords

Humans
Klebsiella pneumoniae/genetics
Anti-Bacterial Agents
Virulence/genetics
Klebsiella Infections/drug therapy

Publisher's Copyright Statement

This full text is made available under CC-BY 4.0. https://creativecommons.org/licenses/by/4.0/

RGC Funding Information

RGC-funded

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10.1038/s41392-023-01490-9

154164487.pdfFinal Published version, 1.53 MBLicence: CC BY

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Cite this

@article{a161f9655ba84afab5aeeb40db075607,

title = "Molecular mechanisms underlying the high mortality of hypervirulent Klebsiella pneumoniae and its effective therapy development",

keywords = "Humans, Klebsiella pneumoniae/genetics, Anti-Bacterial Agents, Virulence/genetics, Klebsiella Infections/drug therapy",

author = "Qi Xu and Miaomiao Xie and Xiaoxuan Liu and Heng Heng and Han Wang and Chen Yang and Chan, \{Edward Wai-Chi\} and Rong Zhang and Guan Yang and Sheng Chen",

year = "2023",

doi = "10.1038/s41392-023-01490-9",

language = "English",

volume = "8",

}

TY - JOUR

T1 - Molecular mechanisms underlying the high mortality of hypervirulent Klebsiella pneumoniae and its effective therapy development

AU - Xu, Qi

AU - Xie, Miaomiao

AU - Liu, Xiaoxuan

AU - Heng, Heng

AU - Wang, Han

AU - Yang, Chen

AU - Chan, Edward Wai-Chi

AU - Zhang, Rong

AU - Yang, Guan

AU - Chen, Sheng

PY - 2023

Y1 - 2023

KW - Humans

KW - Klebsiella pneumoniae/genetics

KW - Anti-Bacterial Agents

KW - Virulence/genetics

KW - Klebsiella Infections/drug therapy

UR - https://www.scopus.com/pages/publications/85160463200

UR - https://www.scopus.com/record/pubmetrics.uri?eid=2-s2.0-85160463200&origin=recordpage

U2 - 10.1038/s41392-023-01490-9

DO - 10.1038/s41392-023-01490-9

M3 - Letter

C2 - 37248259

SN - 2095-9907

VL - 8

JO - Signal Transduction and Targeted Therapy

JF - Signal Transduction and Targeted Therapy

M1 - 221

ER -

Molecular mechanisms underlying the high mortality of hypervirulent Klebsiella pneumoniae and its effective therapy development

Funding

UN SDGs

Research Keywords

Publisher's Copyright Statement

RGC Funding Information

Access Output

Other Access Options

Permanent Link

Other Files and Links

TBRS-ExtU-Lead: Multi-disciplinary Approaches to Tackle the Global Public Health Threat of Hypervirulent and Multidrug-resistant Klebsiella Pneumoniae

RIF: Development of a Colistin/Adjuvant Antimicrobial Regimen That Exhibits Low Toxicity and High Efficacy in Combating Multi-drug-resistant Bacterial Pathogens

Cite this

Molecular mechanisms underlying the high mortality of hypervirulent Klebsiella pneumoniae and its effective therapy development

Funding

UN SDGs

Research Keywords

Publisher's Copyright Statement

RGC Funding Information

Access Output

Other Access Options

Permanent Link

Other Files and Links

Projects

TBRS-ExtU-Lead: Multi-disciplinary Approaches to Tackle the Global Public Health Threat of Hypervirulent and Multidrug-resistant Klebsiella Pneumoniae

RIF: Development of a Colistin/Adjuvant Antimicrobial Regimen That Exhibits Low Toxicity and High Efficacy in Combating Multi-drug-resistant Bacterial Pathogens

Cite this