Molecular Characterization of qnrVC Genes and Their Novel Alleles in Vibrio spp. Isolated from Food Products in China

Yanyan Zhang; Zhiwei Zheng; Edward Wai-Chi Chan; Ning Dong; Xiaodong Xia; Sheng Chen

doi:10.1128/AAC.00529-18

Molecular Characterization of qnrVC Genes and Their Novel Alleles in Vibrio spp. Isolated from Food Products in China

Yanyan Zhang
, Zhiwei Zheng
, Edward Wai-Chi Chan
, Ning Dong
, Xiaodong Xia^*
, Sheng Chen^*

^*Corresponding author for this work

Research output: Journal Publications and Reviews › RGC 21 - Publication in refereed journal › peer-review

23 Citations (Scopus)

Abstract

This study reports the prevalences of qnrVC genes in 74 ciprofloxacin-resistant Vibrio sp. isolates. Two novel functional qnrVC alleles, qnrVC8 and qnrVC9, sharing 98% and 99% nucleotide similarity with qnrVC6 and qnrVC7, respectively, were identified. Our findings suggested that carriage of qnrVC alleles, together with target mutations in gyrA and parC genes, may contribute to the development of fluoroquinolone resistance in Vibrio species, posing a serious threat to public health.

Original language	English
Article number	e00529-18
Journal	Antimicrobial Agents and Chemotherapy
Volume	62
Issue number	7
Online published	26 Jun 2018
DOIs	https://doi.org/10.1128/AAC.00529-18
Publication status	Published - Jul 2018
Externally published	Yes

Research Keywords

Ciprofloxacin resistance
QnrVC
Vibrio

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10.1128/AAC.00529-18

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@article{9be06a35e4b44a0b8e37ffaf6ff94a3c,

title = "Molecular Characterization of qnrVC Genes and Their Novel Alleles in Vibrio spp. Isolated from Food Products in China",

abstract = "This study reports the prevalences of qnrVC genes in 74 ciprofloxacin-resistant Vibrio sp. isolates. Two novel functional qnrVC alleles, qnrVC8 and qnrVC9, sharing 98\% and 99\% nucleotide similarity with qnrVC6 and qnrVC7, respectively, were identified. Our findings suggested that carriage of qnrVC alleles, together with target mutations in gyrA and parC genes, may contribute to the development of fluoroquinolone resistance in Vibrio species, posing a serious threat to public health.",

keywords = "Ciprofloxacin resistance, QnrVC, Vibrio",

author = "Yanyan Zhang and Zhiwei Zheng and Chan, \{Edward Wai-Chi\} and Ning Dong and Xiaodong Xia and Sheng Chen",

year = "2018",

month = jul,

doi = "10.1128/AAC.00529-18",

language = "English",

volume = "62",

journal = "Antimicrobial Agents and Chemotherapy",

issn = "0066-4804",

publisher = "American Society for Microbiology",

number = "7",

}

TY - JOUR

T1 - Molecular Characterization of qnrVC Genes and Their Novel Alleles in Vibrio spp. Isolated from Food Products in China

AU - Zhang, Yanyan

AU - Zheng, Zhiwei

AU - Chan, Edward Wai-Chi

AU - Dong, Ning

AU - Xia, Xiaodong

AU - Chen, Sheng

PY - 2018/7

Y1 - 2018/7

N2 - This study reports the prevalences of qnrVC genes in 74 ciprofloxacin-resistant Vibrio sp. isolates. Two novel functional qnrVC alleles, qnrVC8 and qnrVC9, sharing 98% and 99% nucleotide similarity with qnrVC6 and qnrVC7, respectively, were identified. Our findings suggested that carriage of qnrVC alleles, together with target mutations in gyrA and parC genes, may contribute to the development of fluoroquinolone resistance in Vibrio species, posing a serious threat to public health.

AB - This study reports the prevalences of qnrVC genes in 74 ciprofloxacin-resistant Vibrio sp. isolates. Two novel functional qnrVC alleles, qnrVC8 and qnrVC9, sharing 98% and 99% nucleotide similarity with qnrVC6 and qnrVC7, respectively, were identified. Our findings suggested that carriage of qnrVC alleles, together with target mutations in gyrA and parC genes, may contribute to the development of fluoroquinolone resistance in Vibrio species, posing a serious threat to public health.

KW - Ciprofloxacin resistance

KW - QnrVC

KW - Vibrio

UR - https://www.scopus.com/pages/publications/85049000569

UR - https://www.scopus.com/record/pubmetrics.uri?eid=2-s2.0-85049000569&origin=recordpage

U2 - 10.1128/AAC.00529-18

DO - 10.1128/AAC.00529-18

M3 - RGC 21 - Publication in refereed journal

C2 - 29661884

SN - 0066-4804

VL - 62

JO - Antimicrobial Agents and Chemotherapy

JF - Antimicrobial Agents and Chemotherapy

IS - 7

M1 - e00529-18

ER -

Molecular Characterization of qnrVC Genes and Their Novel Alleles in Vibrio spp. Isolated from Food Products in China

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