Molecular and Structural Evolution of Porcine Epidemic Diarrhea Virus

Research output: Journal Publications and ReviewsRGC 21 - Publication in refereed journalpeer-review

2 Scopus Citations
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Author(s)

  • Baicheng Huang
  • Guoqian Gu
  • Yunjing Zhang
  • Zhenzhen Chen
  • Kegong Tian

Detail(s)

Original languageEnglish
Article number3388
Journal / PublicationAnimals
Volume12
Issue number23
Online published1 Dec 2022
Publication statusPublished - Dec 2022

Link(s)

Abstract

To analyze the evolutionary characteristics of the highly contagious porcine epidemic diarrhea virus (PEDV) at the molecular and structural levels, we analyzed the complete genomes of 647 strains retrieved from the GenBank database. The results showed that the spike (S) gene exhibited larger dS (synonymous substitutions per synonymous site) values than other PEDV genes. In the selective pressure analysis, eight amino acid (aa) sites of the S protein showed strong signals of positive selection, and seven of them were located on the surface of the S protein (S1 domain), suggesting a high selection pressure of S protein. Topologically, the S gene is more representative of the evolutionary relationship at the genome-wide level than are other genes. Structurally, the evolutionary pattern is highly S1 domain-related. The haplotype networks of the S gene showed that the strains are obviously clustered geographically in the lineages corresponding to genotypes GI and GII. The alignment analysis on representative strains of the main haplotypes revealed three distinguishable nucleic acid sites among those strains, suggesting a putative evolutionary mechanism in PEDV. These findings provide several new fundamental insights into the evolution of PEDV and guidance for developing effective prevention countermeasures against PEDV.

Research Area(s)

  • porcine epidemic diarrhea virus, molecular evolution, positive selection, structural assay, haplotypes

Citation Format(s)

Molecular and Structural Evolution of Porcine Epidemic Diarrhea Virus. / Huang, Baicheng; Gu, Guoqian; Zhang, Yunjing et al.
In: Animals, Vol. 12, No. 23, 3388, 12.2022.

Research output: Journal Publications and ReviewsRGC 21 - Publication in refereed journalpeer-review

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