Molecular and Immunophenotypical Characterization of a Feline Immunodeficiency Virus (FIV)-Associated Lymphoma: a Direct Role for FIV in B-Lymphocyte Transformation?

Julia A. BEATTY; John J. CALLANAN; Anne TERRY; Oswald JARRETT; James C. NEIL

doi:10.1128/jvi.72.1.767-771.1998

Molecular and Immunophenotypical Characterization of a Feline Immunodeficiency Virus (FIV)-Associated Lymphoma: a Direct Role for FIV in B-Lymphocyte Transformation?

Julia A. BEATTY
, John J. CALLANAN
, Anne TERRY
, Oswald JARRETT
, James C. NEIL

Research output: Journal Publications and Reviews › RGC 21 - Publication in refereed journal › peer-review

30 Citations (Scopus)

Abstract

We describe the histopathological, immunohistochemical, and molecular characterization of a lymphoma arising in a 7-year-old cat following experimental infection with feline immunodeficiency virus (FIV). The tumor was high grade and of B-cell lineage. The transformed cell had an immature phenotype (CD79a⁺, CD79b^-, CD21^-, immunoglobulin heavy and light chain negative), confirmed by antigen receptor gene analysis, which showed germ line configuration. Single-copy, clonally integrated FIV provirus was detected in tumor genomic DNA. FIV p24 antigen was not detected in tumor cells by immunostaining. This study provides the first evidence that the feline lentivirus may play a direct role in cell transformation under certain circumstances.

Original language	English
Pages (from-to)	767-771
Journal	Journal of Virology
Volume	72
Issue number	1
Online published	1 Jan 1998
DOIs	https://doi.org/10.1128/jvi.72.1.767-771.1998
Publication status	Published - Jan 1998
Externally published	Yes

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title = "Molecular and Immunophenotypical Characterization of a Feline Immunodeficiency Virus (FIV)-Associated Lymphoma: a Direct Role for FIV in B-Lymphocyte Transformation?",

abstract = "We describe the histopathological, immunohistochemical, and molecular characterization of a lymphoma arising in a 7-year-old cat following experimental infection with feline immunodeficiency virus (FIV). The tumor was high grade and of B-cell lineage. The transformed cell had an immature phenotype (CD79a+, CD79b-, CD21-, immunoglobulin heavy and light chain negative), confirmed by antigen receptor gene analysis, which showed germ line configuration. Single-copy, clonally integrated FIV provirus was detected in tumor genomic DNA. FIV p24 antigen was not detected in tumor cells by immunostaining. This study provides the first evidence that the feline lentivirus may play a direct role in cell transformation under certain circumstances.",

author = "BEATTY, \{Julia A.\} and CALLANAN, \{John J.\} and Anne TERRY and Oswald JARRETT and NEIL, \{James C.\}",

year = "1998",

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Molecular and Immunophenotypical Characterization of a Feline Immunodeficiency Virus (FIV)-Associated Lymphoma: a Direct Role for FIV in B-Lymphocyte Transformation? / BEATTY, Julia A.; CALLANAN, John J.; TERRY, Anne et al.
In: Journal of Virology, Vol. 72, No. 1, 01.1998, p. 767-771.

Research output: Journal Publications and Reviews › RGC 21 - Publication in refereed journal › peer-review

TY - JOUR

T1 - Molecular and Immunophenotypical Characterization of a Feline Immunodeficiency Virus (FIV)-Associated Lymphoma

T2 - a Direct Role for FIV in B-Lymphocyte Transformation?

AU - BEATTY, Julia A.

AU - CALLANAN, John J.

AU - TERRY, Anne

AU - JARRETT, Oswald

AU - NEIL, James C.

PY - 1998/1

Y1 - 1998/1

N2 - We describe the histopathological, immunohistochemical, and molecular characterization of a lymphoma arising in a 7-year-old cat following experimental infection with feline immunodeficiency virus (FIV). The tumor was high grade and of B-cell lineage. The transformed cell had an immature phenotype (CD79a+, CD79b-, CD21-, immunoglobulin heavy and light chain negative), confirmed by antigen receptor gene analysis, which showed germ line configuration. Single-copy, clonally integrated FIV provirus was detected in tumor genomic DNA. FIV p24 antigen was not detected in tumor cells by immunostaining. This study provides the first evidence that the feline lentivirus may play a direct role in cell transformation under certain circumstances.

AB - We describe the histopathological, immunohistochemical, and molecular characterization of a lymphoma arising in a 7-year-old cat following experimental infection with feline immunodeficiency virus (FIV). The tumor was high grade and of B-cell lineage. The transformed cell had an immature phenotype (CD79a+, CD79b-, CD21-, immunoglobulin heavy and light chain negative), confirmed by antigen receptor gene analysis, which showed germ line configuration. Single-copy, clonally integrated FIV provirus was detected in tumor genomic DNA. FIV p24 antigen was not detected in tumor cells by immunostaining. This study provides the first evidence that the feline lentivirus may play a direct role in cell transformation under certain circumstances.

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UR - https://www.scopus.com/pages/publications/0031984641#tab=impact

U2 - 10.1128/jvi.72.1.767-771.1998

DO - 10.1128/jvi.72.1.767-771.1998

M3 - RGC 21 - Publication in refereed journal

C2 - 9420284

SN - 0022-538X

VL - 72

SP - 767

EP - 771

JO - Journal of Virology

JF - Journal of Virology

IS - 1

ER -

Molecular and Immunophenotypical Characterization of a Feline Immunodeficiency Virus (FIV)-Associated Lymphoma: a Direct Role for FIV in B-Lymphocyte Transformation?

Abstract

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ERRATA: Molecular and Immunophenotypical Characterization of a Feline Immunodeficiency Virus (FIV)-Associated Lymphoma: a Direct Role for FIV in B-Lymphocyte Transformation?

Cite this