Modulation of NF-κB in rescued irradiated cells

Research output: Journal Publications and Reviews (RGC: 21, 22, 62)21_Publication in refereed journalpeer-review

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Author(s)

  • Y. K. Fung
  • W. Han
  • L. Li
  • S. K. Chiu

Detail(s)

Original languageEnglish
Pages (from-to)37-43
Journal / PublicationRadiation Protection Dosimetry
Volume167
Issue number1-3
Online published24 Apr 2015
Publication statusPublished - Nov 2015

Conference

Title9th International Symposium on the Natural Radiation Environment (NRE)
PlaceJapan
CityHirosaki
Period22 - 26 September 2014

Abstract

Studies by different groups on the rescue effect, where unirradiated bystander cells mitigated the damages in the irradiated cells, since its discovery by the authors’ group in 2011 were first reviewed. The properties of the rescue effect were then examined using a novel experimental set-up to physically separate the rescue signals from the bystander signals. The authors’ results showed that the rescue effect was mediated through activation of the nuclear factor-κB (NF-κB) response pathway in the irradiated cells, and that the NF-κB activation inhibitor BAY-11-7082 did not affect the activation of this response pathway in the irradiated cells induced by direct irradiation.

Research Area(s)

  • DOUBLE-STRAND BREAKS, NECROSIS-FACTOR-ALPHA, DNA-DAMAGE, IONIZING-RADIATION, NITRIC-OXIDE, BYSTANDER RESPONSE, FUTURE-DIRECTIONS, HUMAN FIBROBLASTS, IN-VIVO, CANCER

Citation Format(s)

Modulation of NF-κB in rescued irradiated cells. / Lam, R. K. K.; Fung, Y. K.; Han, W.; Li, L.; Chiu, S. K.; Cheng, S. H.; Yu, K. N.

In: Radiation Protection Dosimetry, Vol. 167, No. 1-3, 11.2015, p. 37-43.

Research output: Journal Publications and Reviews (RGC: 21, 22, 62)21_Publication in refereed journalpeer-review