Modular Metabolic Engineering for Biobased Chemical Production

Research output: Journal Publications and Reviews (RGC: 21, 22, 62)21_Publication in refereed journalpeer-review

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Original languageEnglish
Pages (from-to)152-166
Journal / PublicationTrends in Biotechnology
Issue number2
Online published28 Jul 2018
Publication statusPublished - Feb 2019


Microorganisms can manufacture a wide range of biobased chemicals that are useful for diverse industrial applications. However, the overexpression of heterologous enzymes in recombinant strains often leads to metabolic imbalance, resulting in growth retardation and suboptimal production of the target compounds. Here we discuss the recent development of modular metabolic engineering approaches that enable the global fine-tuning of engineered pathways by modularizing the synthetic pathway in single or multiple hosts. In particular, we highlight applications with microbial consortia. To build a vibrant biobased economy, multivariate modular metabolic engineering (MMME), modular coculture engineering (MCE), and spatiotemporal and integrative genome-scale metabolic modeling can be exploited to expedite strain optimization and improve the production of a broad variety of high-value biobased chemicals.

Research Area(s)

  • biobased chemicals, coculture, genome-scale metabolic model, modular engineering