Mitochondrial Delivery of Therapeutic Agents by Amphiphilic DNA Nanocarriers

Research output: Journal Publications and Reviews (RGC: 21, 22, 62)21_Publication in refereed journalpeer-review

23 Scopus Citations
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Author(s)

  • Jonathan Weng-Thim Ho
  • Man Lee Chan
  • Di Xu
  • Man Shing Wong
  • Pik Kwan Lo

Detail(s)

Original languageEnglish
Pages (from-to)770-781
Journal / PublicationSmall
Volume12
Issue number6
Online published21 Dec 2015
Publication statusPublished - 10 Feb 2016

Abstract

The first example of mitochondrial delivery of the anticancer drug doxorubicin (Dox) is presented by lipid-functionalized DNA nanocages (LNCs). Dox localized in mitochondria induces significant cytotoxicity and cellular apoptosis in MCF-7 compared with Dox localized in lysosomes. These results suggest that LNC has the potential to be an outstanding tool in the treatment of specific organelle-related diseases such as cancers.

Research Area(s)

  • anticancer drugs, delivery, DNA nanocarriers, lipophilic molecules, mitochondria

Citation Format(s)

Mitochondrial Delivery of Therapeutic Agents by Amphiphilic DNA Nanocarriers. / Chan, Miu Shan; Tam, Dick Yan; Dai, Ziwen; Liu, Ling Sum; Ho, Jonathan Weng-Thim; Chan, Man Lee; Xu, Di; Wong, Man Shing; Tin, Chung; Lo, Pik Kwan.

In: Small, Vol. 12, No. 6, 10.02.2016, p. 770-781.

Research output: Journal Publications and Reviews (RGC: 21, 22, 62)21_Publication in refereed journalpeer-review