Mitochondrial Delivery of Therapeutic Agents by Amphiphilic DNA Nanocarriers
Research output: Journal Publications and Reviews (RGC: 21, 22, 62) › 21_Publication in refereed journal › peer-review
Author(s)
Related Research Unit(s)
Detail(s)
| Original language | English |
|---|---|
| Pages (from-to) | 770-781 |
| Journal / Publication | Small |
| Volume | 12 |
| Issue number | 6 |
| Online published | 21 Dec 2015 |
| Publication status | Published - 10 Feb 2016 |
Link(s)
Abstract
The first example of mitochondrial delivery of the anticancer drug doxorubicin (Dox) is presented by lipid-functionalized DNA nanocages (LNCs). Dox localized in mitochondria induces significant cytotoxicity and cellular apoptosis in MCF-7 compared with Dox localized in lysosomes. These results suggest that LNC has the potential to be an outstanding tool in the treatment of specific organelle-related diseases such as cancers.
Research Area(s)
- anticancer drugs, delivery, DNA nanocarriers, lipophilic molecules, mitochondria
Citation Format(s)
Mitochondrial Delivery of Therapeutic Agents by Amphiphilic DNA Nanocarriers. / Chan, Miu Shan; Tam, Dick Yan; Dai, Ziwen; Liu, Ling Sum; Ho, Jonathan Weng-Thim; Chan, Man Lee; Xu, Di; Wong, Man Shing; Tin, Chung; Lo, Pik Kwan.
In: Small, Vol. 12, No. 6, 10.02.2016, p. 770-781.Research output: Journal Publications and Reviews (RGC: 21, 22, 62) › 21_Publication in refereed journal › peer-review
