Abstract
Mitochondria are important subcellular organelles that play a key role in energy production and cellular metabolism. An increase in the mitochondrial membrane potential (MMP) is a characteristic feature of cancer and cardiovascular disease. In this study, we designed and synthesized a series of BODIPY dyes (BODIPY-Mito-n) for mitochondria-targeted imaging. These BODIPY dyes displayed high fluorescence quantum yields in biologically relevant media, and showed high MMP-sensitive mitochondrial localization. Notably, the incorporation of poly(ethylene glycol) chains to the phosphonium cation unit significantly improved the biocompatibility of the probes. The high MMP sensitivity and enhanced biocompatibility of the probes make them potential candidates for reporting on changes in mitochondrial function in cancer and cardiovascular disease.
| Original language | English |
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| Publication status | Presented - 9 Jun 2025 |
| Event | The 17th International Symposium for Chinese Organic Chemists (ISCOC) & The 14th International Symposium for Chinese Inorganic Chemists (ISCIC) - Hong Kong Ocean Park Marriott Hotel, Hong Kong, Hong Kong Duration: 9 Jun 2025 → 11 Jun 2025 https://www.iscc2025.hk/ |
Conference
| Conference | The 17th International Symposium for Chinese Organic Chemists (ISCOC) & The 14th International Symposium for Chinese Inorganic Chemists (ISCIC) |
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| Abbreviated title | ISCOC-17 and ISCIC-14 |
| Country/Territory | Hong Kong |
| City | Hong Kong |
| Period | 9/06/25 → 11/06/25 |
| Internet address |
Bibliographical note
Information for this record is provided by the author(s) concerned.Funding
We thank “Laboratory for Synthetic Chemistry and Chemical Biology” under the Health@InnoHK Program launched by Innovation and Technology Commission, The Government of HKSAR, P. R. China for financial support.