MiR-637 maintains the balance between adipocytes and osteoblasts by directly targeting Osterix

Research output: Journal Publications and Reviews (RGC: 21, 22, 62)21_Publication in refereed journalpeer-review

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Author(s)

  • Jin-Fang Zhang
  • Wei-Ming Fu
  • Hua Wang
  • Wei-Mao Wang
  • Shi-Cang Yu
  • Xiu-Wu Bian
  • Jin Zhou
  • Marie C. M. Lin
  • Gang Lu
  • Wai-Sang Poon
  • Hsiang-Fu Kung

Detail(s)

Original languageEnglish
Pages (from-to)3955-3961
Journal / PublicationMolecular Biology of the Cell
Volume22
Issue number21
Publication statusPublished - 1 Nov 2011
Externally publishedYes

Abstract

Bone development is dynamically regulated by homeostasis, in which a balance between adipocytes and osteoblasts is maintained. Disruption of this differentiation balance leads to various bone-related metabolic diseases, including osteoporosis. In the present study, a primate-specific microRNA (miR-637) was found to be involved in the differentiation of human mesenchymal stem cells (hMSCs). Our preliminary data indicated that miR-637 suppressed the growth of hMSCs and induced S-phase arrest. Expression of miR-637 was increased during adipocyte differentiation (AD), whereas it was decreased during osteoblast differentiation (OS), which suggests miR-637 could act as a mediator of adipoosteogenic differentiation. Osterix (Osx), a significant transcription factor of osteoblasts, was shown to be a direct target of miR-637, which significantly enhanced AD and suppressed OS in hMSCs through direct suppression of Osx expression. Furthermore, miR-637 also significantly enhanced de novo adipogenesis in nude mice. In conclusion, our data indicated that the expression of miR-637 was indispensable for maintaining the balance of adipocytes and osteoblasts. Disruption of miR-637 expression patterns leads to irreversible damage to the balance of differentiation in bone marrow. © 2011 Zhang et al.

Citation Format(s)

MiR-637 maintains the balance between adipocytes and osteoblasts by directly targeting Osterix. / Zhang, Jin-Fang; Fu, Wei-Ming; He, Ming-Liang; Wang, Hua; Wang, Wei-Mao; Yu, Shi-Cang; Bian, Xiu-Wu; Zhou, Jin; Lin, Marie C. M.; Lu, Gang; Poon, Wai-Sang; Kung, Hsiang-Fu.

In: Molecular Biology of the Cell, Vol. 22, No. 21, 01.11.2011, p. 3955-3961.

Research output: Journal Publications and Reviews (RGC: 21, 22, 62)21_Publication in refereed journalpeer-review