Miniaturized electromechanical devices for the characterization of the biomechanics of deep tissue

Research output: Journal Publications and Reviews (RGC: 21, 22, 62)21_Publication in refereed journalpeer-review

1 Scopus Citations
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Author(s)

  • Enming Song
  • Zhaoqian Xie
  • Wubin Bai
  • Haiwen Luan
  • Bowen Ji
  • Xin Ning
  • Yu Xia
  • Janice Mihyun Baek
  • Yujin Lee
  • Raudel Avila
  • Huang-Yu Chen
  • Jae-Hwan Kim
  • Surabhi Madhvapathy
  • Mengdi Han
  • Sang Min Won
  • Xinyuan Zhang
  • Daniel J. Myers
  • Yongfeng Mei
  • Xu Guo
  • Shuai Xu
  • Jan-Kai Chang
  • Yonggang Huang
  • John A. Rogers

Related Research Unit(s)

Detail(s)

Original languageEnglish
Pages (from-to)759–771
Journal / PublicationNature Biomedical Engineering
Volume5
Issue number7
Online published27 May 2021
Publication statusPublished - Jul 2021

Abstract

Evaluating the biomechanics of soft tissues at depths well below their surface, and at high precision and in real time, would open up diagnostic opportunities. Here, we report the development and application of miniaturized electromagnetic devices, each integrating a vibratory actuator and a soft strain-sensing sheet, for dynamically measuring the Young’s modulus of skin and of other soft tissues at depths of approximately 1–8 mm, depending on the particular design of the sensor. We experimentally and computationally established the operational principles of the devices and evaluated their performance with a range of synthetic and biological materials and with human skin in healthy volunteers. Arrays of devices can be used to spatially map elastic moduli and to profile the modulus depth-wise. As an example of practical medical utility, we show that the devices can be used to accurately locate lesions associated with psoriasis. Compact electronic devices for the rapid and precise mechanical characterization of living tissues could be used to monitor and diagnose a range of health disorders.

Citation Format(s)

Miniaturized electromechanical devices for the characterization of the biomechanics of deep tissue. / Song, Enming; Xie, Zhaoqian; Bai, Wubin; Luan, Haiwen; Ji, Bowen; Ning, Xin; Xia, Yu; Baek, Janice Mihyun; Lee, Yujin; Avila, Raudel; Chen, Huang-Yu; Kim, Jae-Hwan; Madhvapathy, Surabhi; Yao, Kuanming; Li, Dengfeng; Zhou, Jingkun; Han, Mengdi; Won, Sang Min; Zhang, Xinyuan; Myers, Daniel J.; Mei, Yongfeng; Guo, Xu; Xu, Shuai; Chang, Jan-Kai; Yu, Xinge; Huang, Yonggang; Rogers, John A.

In: Nature Biomedical Engineering, Vol. 5, No. 7, 07.2021, p. 759–771.

Research output: Journal Publications and Reviews (RGC: 21, 22, 62)21_Publication in refereed journalpeer-review