TY - GEN
T1 - Mimicking Dividing Cells by Assembly of Protein Structures Inside Aqueous Two-Phase Droplets
AU - Shum, HC
AU - Song, Y
AU - Knowles, T
AU - Michaels, T
N1 - Publication details (e.g. title, author(s), publication statuses and dates) are captured on an “AS IS” and “AS AVAILABLE” basis at the time of record harvesting from the data source. Suggestions for further amendments or supplementary information can be sent to [email protected].
PY - 2018/11/25
Y1 - 2018/11/25
N2 - In this work, we demonstrate that assembly of macromolecules, such as proteins, can cause aqueous droplets to exhibit division, even in the absence of a cell membrane. The all-aqueous nature of the systems results in tunable interfacial tension, affinity partitioning and osmotic responses. The solubility of_x000D_
different types of macromolecules across the interfaces enables new strategies to assemble structures at the droplet interfaces. While the significantly lower interfacial tension can make stabilization of the interface difficult due to the slow adsorption dynamics by surfactants and particles, structures that have_x000D_
been assembled at the interfaces can be easily expelled. This contributes to the more sophisticated dynamics of the hierarhically structured all-aqueous droplets. These droplets have great potential to be utilized as templates for fabricating materials with novel properties.
AB - In this work, we demonstrate that assembly of macromolecules, such as proteins, can cause aqueous droplets to exhibit division, even in the absence of a cell membrane. The all-aqueous nature of the systems results in tunable interfacial tension, affinity partitioning and osmotic responses. The solubility of_x000D_
different types of macromolecules across the interfaces enables new strategies to assemble structures at the droplet interfaces. While the significantly lower interfacial tension can make stabilization of the interface difficult due to the slow adsorption dynamics by surfactants and particles, structures that have_x000D_
been assembled at the interfaces can be easily expelled. This contributes to the more sophisticated dynamics of the hierarhically structured all-aqueous droplets. These droplets have great potential to be utilized as templates for fabricating materials with novel properties.
M3 - RGC 32 - Refereed conference paper (with host publication)
T3 - Materials Research Society (MRS) Fall Meeting 2018
BT - Materials Research Society (MRS) Fall Meeting 2018
PB - Materials Research Society
T2 - Materials Research Society (MRS) Fall Meeting 2018
Y2 - 25 November 2018 through 30 November 2018
ER -